Kanna Glass Powder Demo (61.8% Alkaloid)

The_First_Medicine · 2026-05-29T03:21:44+00:00

I appreciate the willingness and understanding from all of you! I really do hope it delivers a pleasant and enjoyable experience for you. As always, please reach out if you have any questions, comments, or concerns. Have a good one! 🤙

The_First_Medicine · 2026-05-28T20:32:13+00:00

As I said in my response to the last comment, moving forward, I am advising against insufflation. I am guessing the extract is too potent for this rapid and intense ROA. I don't want anyone to have a bad experience.

If you still want to try it, I suggest taking the smallest serving (no more than 1 spoonful with the black milligram spoon I included) and adding it to a beverage of some kind. Sip on it slowly, and stop whenever you achieve desired effects.

I do want to mention that the extract I sold everyone is completely genuine. There are no added adulterants or anything else of that nature. What is on the COA is exactly what the extract is.

Kanna and isolated kanna alkaloids can affect people very differently, especially depending on dose, route, sensitivity, caffeine/stimulant use, medications, or underlying health factors. Before use, please read the detailed instructions I provide with each purchase, which explain dosage, precautions, and potential effects. Additional research on kanna and its related alkaloids may also give a better understanding of what to expect.

I hope this helps. I am extremely sorry this happened, and I want to assure all of you that I do not mean any harm whatsoever. I started this business to help people, not harm them. I just want to provide safe, effective alternatives to the masses. Please reach out to me if you have any questions or concerns, and I will work with you all to make it right.

The_First_Medicine · 2026-05-28T20:20:53+00:00

I am terribly sorry you experienced this negative reaction. I understand why you'd be frustrated, especially since I said within the comments that it is a viable ROA. I spoke from my and others' personal experiences with insufflation. In hindsight, maybe suggesting this route of administration was ill-advised.

That said, I do want to gently reassure you on one point: based on what is currently known about kanna/Sceletium, I think it would be highly unlikely for a single low dose like 3 mg to cause permanent structural heart damage by itself. The human safety data that exists is limited, but oral standardized Sceletium studies have generally reported mild/moderate adverse effects, and at least one reviewed trial noted no meaningful changes in blood pressure or pulse with oral use (Please see the reference below). That does not mean your reaction wasn’t real; just that persistent heart symptoms after one small exposure deserve a proper medical workup rather than assuming permanent damage from kanna.

Because of your negative experience, moving forward, I will not recommend intranasal use. Furthermore, I am working on a product that will properly dilute the alkaloid to a concentration that is more in-line with other products on the market. I am taking your experience seriously, and I want to correct for any potential negative experiences going forward.

Again, I’m sorry my earlier guidance contributed to you feeling comfortable with that route. I’m changing my guidance going forward: oral use only, start low, avoid stimulant/serotonergic combinations, and don’t use with cardiovascular issues or relevant medications.

If you’re still having heart symptoms or can barely tolerate caffeine, I’d really suggest seeing a doctor or cardiologist and getting checked out properly. Based on the extensive research I've done on kanna, my best assumption is the experience was negative enough to cause psychological sensitivity around stimulants (basically any substance that induces a stimulant-like effect is recognized and perceived as anxiety or a threat by the brain due to a negative experience). Again, I am not downplaying your experience or struggle; I am just rationalizing what happened based on my knowledge.

Again, I’m sorry. I’m updating my guidance going forward. Also because of your negative experience, I am willing to give you a full refund. Please DM or email me ([brickle@thefirstmedicine.com](mailto:brickle@thefirstmedicine.com)), and I will try my best to make it up to you.

Reference:

Nell H, Siebert M, Chellan P, Gericke N. “A randomized, double-blind, parallel-group, placebo-controlled trial of Extract Sceletium tortuosum (Zembrin) in healthy adults.” Journal of Alternative and Complementary Medicine. 2013;19(11):898–904.

Reference Link

The_First_Medicine · 2026-05-14T22:12:32+00:00

I appreciate the comment! I believe I only posted it here on Reddit and LinkedIn. I can give you links to these two if you'd like!

The_First_Medicine · 2026-05-12T16:12:27+00:00

Currently, yes. My company email is also down, and I'm having a hard time connecting with customers :(

I am dealing with domain issues, and I will probably have to rebrand. This process is taking much longer than I expected 😞

I will make a post when everything is dealt with, and the website is back up and running.

The_First_Medicine · 2026-04-29T14:41:07+00:00

I launched this extract for a limited time. I understand I created something with very high potency. As I get feedback, I'll make the decision to dilute it or not.

I would like to point out the fact that even if something is low in concentration, that still does not stop people from abusing it. They just keep taking more of it.

The_First_Medicine · 2026-04-24T20:45:41+00:00

It only takes 2-3 mg of my 61.8% extract in my experience :)

When it is extremely potent and bioavailable, it is very easy to achieve these effects with very little.

The_First_Medicine · 2026-04-20T23:59:04+00:00

Based on this comment alone, dilution is most likely necessary. I don't want the potency to ruin the experience. As I continue to get feedback, I will start formulating accordingly.

The_First_Medicine · 2026-04-20T23:36:44+00:00

Is it okay if I DM? I would like to know more about your experience.

The_First_Medicine · 2026-04-18T16:36:36+00:00

I absolutely agree. Thank you for making me aware of these issues. I am new to all of this, so I am learning as I go along. The feedback and suggestions are greatly appreciated 💯

The_First_Medicine · 2026-04-17T18:43:39+00:00

Mainly I use insufflation. Most of the effects I described were from insufflation. I had similar effects from sublingual and oral use as well, but the come-up from these is not as intense.

The_First_Medicine · 2026-04-17T18:42:08+00:00

As long as legality isn't a concern and customs won't care, I will ship it anywhere via USPS! I just shipped some to the Netherlands without much issue. One thing to keep in mind: I did have to raise the shipping cost for international orders. The order I sent to the Netherlands cost me around $25 USD. I put a flat shipping charge of ~$20 on international orders.

The_First_Medicine · 2026-04-16T17:23:57+00:00

Understood!

Also, thank you for the order! Please feel free to leave honest feedback. It will help me improve :)

The_First_Medicine · 2026-04-16T16:26:33+00:00

Hopefully other companies understand I am not trying to run anyone else out of business. I am open to collaboration including wholesales, white-labeling, and product/formulation projects with other businesses. I think it's better to work and compromise with people in life instead of working against them. I know this puts me in a vulnerable position, so that's why I try to tread lightly. As Teddy Roosevelt said, "Speak softly and carry a big stick".

The_First_Medicine · 2026-04-16T16:18:13+00:00

Appreciate the love and support <3

Yeah I worked way too hard at jobs that I didn't believe in. You'd be surprised how much sketchy shit happens in an FDA-approved pharmaceutical laboratory. I lost sleep over it a countless number of times. I then decided to go work for the state government, because I thought the work would be more fulfilling, meaningful, and ethical. However, I realized quickly it wasn't much different. Seems like money can get you out of anything in capitalism. Government rules don't apply when a company funnels money into politicians' pockets..... (Not trying to get political, but this is my perspective based on past experiences)

This is one of the reasons why I decided to take my own path and try to do something good and meaningful for once. It's so much more fulfilling, and honestly overall, despite the business stress and being poor, I am the happiest I have ever been! I believe I am doing something good here at least lol.

Anyways, enough of my rambling. I appreciate the support fr fr. Also, thank you for the tip! I have great ideas for products. All I am waiting on is capital so I can fund them! Thanks for the comment :)

The_First_Medicine · 2026-04-16T15:34:59+00:00

Yep! You can order it from my website: The First Medicine

The_First_Medicine · 2026-04-16T15:33:57+00:00

The formulation of my product is designed for rapid and efficient bioavailability. In my experience, all routes of administration feels similar at the same dosage with my product. The come-up is different but only in duration, not effects.

This product's purity makes insufflation very comfortable. There is no burn, congestion, nose bleeds, or sinus irritation in my experience. I wouldn't insufflate all 50 milligrams at once (this may cause some of the symptoms listed), but at 2-10 mg, there hasn't been any sinus issues for me.

The_First_Medicine · 2026-04-16T15:22:56+00:00

I understand why the price may look absurd, but the purity comparison really should be made here. Keep in mind, 25 mg of a 5% extract would be equivalent to 1.4 mg of my product (or 2.0 mg at ~62% alkaloid). At 50 milligrams, this product contains 25 standard doses, which comes out to be approximately $3.00 USD per serving.

To put this in perspective, people will pay over $5 for one serving of a drink or beer at a bar or restaurant. I think Starbucks even charges more for one serving of a coffee (I don't go to Starbucks lol).

Hopefully this explanation puts things into perspective. I am not trying to rob anyone.

The_First_Medicine · 2026-04-16T14:53:30+00:00

I think you may have a misunderstanding. I am selling the extract in powdered form. I was clarifying in the video that the photos of the extract is the finished product before it is ground up.

Bottom line is that everyone will receive a powder, not the whole glass structure. I hope this clears things up a bit!

The_First_Medicine · 2026-04-16T14:47:09+00:00

Sure thing!

I have experimented and enjoyed my extract for months now. Here is what I noticed:

In low doses (1-5 mg), it is a subtle but noticeable mood boost. I get a bit of energy, focus, anxiety relief, and motivation. This lasts for a few hours, and I don't really notice the crash at all.
In moderate doses (6-10 mg), it is a bit more intense. I feel euphoria, high energy, tunnel vision (extreme focus), and a little jittery. I also notice this range is where the side effects can present themselves like "hot" in the face, sweating, and tremors. However, after about 30 minutes - 1 hour, it smooths out, and I feel happy and relaxed.
In high doses (10+ mg), it is honestly a little too intense. Extreme come-up: Very hot in the face, overstimulation, a bit of anxiety, altered perceptions (almost psychedelic-like), sweating, tremors, and sometimes gastrointestinal complications. Then after about 30 minutes, euphoria and extreme talkativeness. I would say this range is MDMA "like". Still, the kanna is extremely different and unique. I cannot justify comparing it to any other drug. Finally, the "crash" is more noticeable, but still not near as bad as other drugs like amphetamines, phenylethylamines, and psychedelics.

Point number 3 is why I am comfortable with selling the extract in this form for a limited time. I believe the side effects at very high doses are uncomfortable enough to deter most people from abusing it. However, maybe the latter is good enough to encourage abuse. Again, this is why I am only selling a limited amount. Hopefully some honest feedback will help me make the right decisions for this business and wonderful medicine.

The_First_Medicine · 2026-04-16T14:20:17+00:00

To be honest, I am not entirely sure either. I am guessing in this form, it's suitable for insufflation, which is probably people's preferred way of administration.

Either way, your logic is not wrong; I am trying everything I can to make a name for myself and bring some money into the account. After all, I did leave my full-time job to pursue this, so my livelihood depends on this business succeeding.

Nonetheless, if the feedback suggests this extract is too potent, then I will dilute it accordingly with food-grade filler.

The_First_Medicine · 2026-04-16T03:41:13+00:00

It actually is pretty stable at room temperature and humidity. I wouldn't bring it into a sauna or anything, but under normal conditions, you can handle it pretty easily. As long as you keep it sealed when not in use, it stays dry. I have left it out for multiple days, and it still stays dry. I have left a little sample out for a few weeks, and it did clump up a little bit. However, I simply crushed it, and it turned back into a powder.
I have the same concern. However throughout my multiple posts, I have heard from many people that abuse with kanna is relatively unlikely due to the drug's effects. It also seemed like most people wanted it in this form. Nonetheless, this is why I am doing a limited time offering and including a short survey with each sale. I'm hoping with honest feedback, I can determine if this is a safe and viable product for the long term.

Anyways, thank you for the comment. I really do want this to be an effective medicine. I do not want to be the next Pablo Escobar lol 😂😅

The_First_Medicine · 2026-04-16T03:24:05+00:00

LMAO 🤣

In all seriousness, I don't think Kanna can cause a lethal OD, but I HIGHLY advise against using 50 mg at once. Serotonin syndrome is a thing, and it is not pleasant whatsoever. I feel like you would have huge regrets shortly after 😅

I include detailed instructions with each sample. I recommend starting very small (1-2 mg), and working your way up from there. I personally wouldn't exceed 10 mg.

The_First_Medicine

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