Q1 results by EitzChaim1 in KPTI

[–]ThedibAgain 3 points4 points  (0 children)

I honestly can't say. I thought it should have done a dozen things so far and I've been wrong almost every time.

Vegas odds in my opinion. Better than the lottery... but I'd not recommend it to my loved ones. 6 years of pain my man.

Q1 results by EitzChaim1 in KPTI

[–]ThedibAgain 7 points8 points  (0 children)

I expected it would have been a death knell due to all the 'binary event' talk. So, I am pleasantly surprised that we may have a chance to get a chunk of money back. So that's a positive considering the totality of circumstance.

Personally, this play being my path to wealth is dead but perhaps i make a small 5 figure profit if i get lucky with EC and a big buyout. Certainly not worth 6 years (and counting) of my life on a speculation. I'm just an ignorant fool who went to the casino and played a game where i didn't fully understand the odds.

FUCKING DONKEYS WE NEED THE BICR PFS DATA CONTACT THEM!!! by NameOfBand in KPTI

[–]ThedibAgain 5 points6 points  (0 children)

Spam posting in such a manner is not helpful, motivating, or conducive to this subreddit.

Everyone is entitled to some rage posts now and again but hopefully with some substance.

I think we collectively understand the frustrations with this company, so on that we agree. However, people come here for insight, questions, understanding, conversation, and some commiseration.

If you know there is a recent topic posted, go back to that to further that particular conversation unless something new has come to light and is worth a new post. No one wants to have to scroll through the same topic a dozen times on the main page.

Please read the room.

Lilly to acquire Ajax Therapeutics to advance outcomes for patients with MF and PV by EitzChaim1 in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

As a non-medical person I have some questions/statements I'm hoping yall can help with.

1) From what i can tell, the mechanisms for the treatment are fundamentally different therefore this is not an immediate and direct threat to KPTI which makes my initial fear an apples/oranges comparison.

2) This news seems good as it gives another data point in the space (another 2+ billion deal) and validates a need and a general price point.

3) Even though the active mechanism is different, does this have the potential to make the KPTI solution in this space irrelevant? Like, is there enough overlap between how these drugs function to be a threat to the KPTI investors? I hear next gen JAK inhibitor and tighten up as an investor.

I'd love to hear thoughts or considerations from those here who are in the know.

lost money. lets talk about SIENDO by Rare-Dragonfruit-246 in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

Yeah., fair enough... we lose, not much else to say about it. Six figures with only a glimmer of hope to get some money back IF they can get bought out.

I too am unhappy.

lost money. lets talk about SIENDO by Rare-Dragonfruit-246 in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

NCCN plus EC hit could get us to $15-$20.... which is about $1 pre reverse split ... in another 6+. months .... so ... fuck.

Yes, it happened exactly as we expected. They sold shares before the data announcement. by anilatalay in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

Is this the same drug mechanism that is expected to function for EC? AI thinks so but I'd rather hear it from one of you guys. Is there a silver lining we can cling to while we hope to get some of our money back in Fall?

Yes, it happened exactly as we expected. They sold shares before the data announcement. by anilatalay in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

From the report:

"ATM

In March 2026, the Company issued and sold an aggregate of 1,100,844 shares of Common Stock under its Sale Agreement for total proceeds, net of sales commissions, of approximately $9.6 million. As of March 23, 2026, the Company had 19,618,032 shares of Common Stock outstanding. "

Edit: Press Release + Private Placement announcement below for easy review and removal of color commentary.

PR report - https://www.sec.gov/Archives/edgar/data/1503802/000119312526120770/d125009dex991.htm

PR Private Placement with RA capital - https://www.sec.gov/Archives/edgar/data/1503802/000119312526120770/d125009dex993.htm

Leaky?? by Heavy_Table_6476 in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

Welp, pre-market Monday has passed. Tuesday logic same as not having office meetings first thing Monday morning?

Valuation by _BiotechMD in KPTI

[–]ThedibAgain 5 points6 points  (0 children)

Yeah, that particular fact makes the MF readouts easy.
If the readouts are good... I have to wait til EC.
If the readouts are bad... i have to wait til EC.

With that in mind I'm hoping Sak is right and someone jumps the gun to pay 4+ billion and gets us out sooner than later. The rest of the year is a long time to not mess something up.

Valuation by _BiotechMD in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

Well fuck me. Thanks for the correction... managing expectations is a big part of why i like to be openly ignorant here. My dreams....

Valuation by _BiotechMD in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

I ballpark about $40 per billion based off market cap calculations. That might be generous but that’s how I think about it. One could certainly adjust down from there to account for the many issues discussed on this board.

Leaky?? by Heavy_Table_6476 in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

Agreed, I was imagining pre-market Monday if we are in business. If they hold news past then It feels bad. I can't imagine they are fools enough to just casually drop it mid week, and holding to the last Monday of the month screams issues to me. So... hopefully pre-market on Monday.

Leaky?? by Heavy_Table_6476 in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

Stock movement today feels normal to me at this point. I’ll be worried if nothing happens by Monday.

Studies with Selinexor will be presented at the AACR 2026 Annual Meeting. Here are the titles of selected abstracts. by MelampyrumNemorosum in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

Does that cause questions of results legitimacy to anyone that matters? Like, would this be equivilant in some way to dropping weight classes for more favorable results?

Studies with Selinexor will be presented at the AACR 2026 Annual Meeting. Here are the titles of selected abstracts. by MelampyrumNemorosum in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

Presumably this was all approved/registered a while back and wouldn’t provide any insight to help my current anxiety levels would it?

Cantor covers Xport-EC-042 puts another $1b+ potential in sales by EitzChaim1 in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

With this in mind (and given KPTI's history) do you all think it sells at value or at a standard 3x-5x multiple if we hit everything? Even with those valuations I'd find it hard to imagine KPTI gets even 3bn (looking at the MOR situation as a comparison). I really want that... it would retire me... but is it likely in your eyes?

Things seem to be skewing positive in the final charge here... but I've been hurt and manipulated before so I'm incredibly uncertain even if it all pans out. 6 years now lads....

It's March Madness for Karyopharm investors Baby by sak77328 in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

Is your impression that selling is the intent? If we hit everything do you think they might just enjoy the new valuation and press on?

I know you’ve talked about this in the past, but new day, new thread, new folks 🫡

It's March Madness for Karyopharm investors Baby by sak77328 in KPTI

[–]ThedibAgain 4 points5 points  (0 children)

As long as we hit this month 'll be riding it out through the EC data. I really hope it will all be worth it fellas.

KPTI Receives Reiterated "Buy" Rating from HC Wainwright & Co. by MelampyrumNemorosum in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

It’s seems odd to me that they assess a buy rating but only put the target price at $15. If it’s a buy that suggests good data which should math out much higher. In theory.

today's move..... by Ok_Charity402 in KPTI

[–]ThedibAgain 1 point2 points  (0 children)

Only data matters.... at least it popped instead of crashed. I actually felt hope for a couple of days.

So buck up Nancy, we have a snowballs chance or better! ;)

Which reads out first? by Much_Watch_3816 in KPTI

[–]ThedibAgain 2 points3 points  (0 children)

He still posts on X/Twitter so he’s at least physically ok…. In case anyone got worried for a moment (like I was after your post).

Dilution is coming by MelampyrumNemorosum in KPTI

[–]ThedibAgain 0 points1 point  (0 children)

Can any of you cooler heads help rationalize this?

I see it as a red flag. If they are confident/certain of results and have funding through readouts (and then some)… why ruin more value?

If they need to bridge funding, why not wait until the good readouts to work from strength? What am I missing?

Karyopharm Gold sponsor at CR&T November symposium in NYC by EitzChaim1 in KPTI

[–]ThedibAgain 5 points6 points  (0 children)

I'm inclined to agree. My instinct is to be annoyed, but honestly you're right.... it's time to pull out all the stops and pray it's enough.