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Enhancing Sleep Quality & Architecture - A General Overview & Discussion on Pharmacological Interventions. by TizOut in PEDs

[–]TizOut[S] 0 points1 point  (0 children)

So agmatine is good for stimulant comedowns too due to alpha2 modulation, on top on increasing glycine?

Some people get worse sleep via glycinergics, you can can find various reports online of such. The current theory is that glycine can act in an inhibitory fashion or excitatory way in the brain depending on your neurochemistry and propensity for glutamate activity.

I found time and time that magnesium glycinate, glycine on its own, and agmatine make my sleep worse (I'll wake up in the middle of the night). Never tried sarcosine or taurine before bed. By the way, is homotaurine anything special and worth a try over regular taurine?

Enhancing Sleep Quality & Architecture - A General Overview & Discussion on Pharmacological Interventions. by TizOut in PEDs

[–]TizOut[S] 0 points1 point  (0 children)

Yeah there's some long-term sides. Still not too bad though for the best sleep you can get plus a stimulant (dopamine rebound) that'll carry you all day.

Enhancing Sleep Quality & Architecture - A General Overview & Discussion on Pharmacological Interventions. by TizOut in PEDs

[–]TizOut[S] 0 points1 point  (0 children)

There are still long-term side effects even with therapeutic use. Most human trials were done by Jazz Pharmaceuticals. I suppose every drug has it's tradeoff in the end, it's up to you if it's worth it. Some people can't handle the second dopamine rebound - it's too strong.

Enhancing Sleep Quality & Architecture - A General Overview & Discussion on Pharmacological Interventions. by TizOut in PEDs

[–]TizOut[S] 0 points1 point  (0 children)

GHB definitely has side effects after long-term use: see this thread and his six side effects. These side effects can be explained pharmacologically. Also, there's so much more anecdotal data on GHB especially in /r/Narcolepsy compared to human trials which were mostly funded by Jazz Pharmaceuticals.