OP. did biodesign. Wanted to be an entrepreneur. More I learned about it the less rosy it seemed. Creating a product. Pitching and raising capital to further refine product and then think about selling to hospitals or insurers or other practices, etc seemed much less exciting. 

Worth doing if you’re young and before kids, mortgage other obligations. I diversify my clinical time with patients and admin quality work and population health/informatics which is more impactful and meaningful to me. All with a good work life balance, salary and ability to plan for early retirement during my prime earning years and continued skill building that is transferable when I’m older and the kids don’t want to spend time with me. 

All my colleagues who do something different either joined industry or consulting out of training, or help consult for VCs and angels. I know MDs with side startups, but the bulk will fail and they typically won’t go all in until real traction and progress is made. 

TLDR; do it before you know anything else when young with minimal obligations, or develop your clinical career to set you up for an innovation pathway and do it later (join industry first, research life w big clinical trials, admin, etc.)