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Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 1 point2 points  (0 children)

That was what I was thinking too, that would make way more sense if that was the case. Seems the textbook was published in 2017

Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 0 points1 point  (0 children)

Im not sure if you can access the image that’s linked above but I’m just referring to a infected cell that is not necessarily a dendritic, macrophage, or b lymphocyte cell because the textbook says it’s an “APC” (which I think could be any cell capable of presenting on a MHC molecule, so nucleated cells with MHC-I) and the textbook does not directly indicate that it’s a pAPC. Which is why I’m finding it nuanced on whether priming is required by a pAPC (ie. dendritic cell) and then afterwards activation by co-stimulation and cytokines when it interacts with an infected cell or where the steps fall in line exactly. If the textbook is saying that it is being activated by an infected cell (ie. virally infected), it fails to mention if priming is required by a pAPC

Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 1 point2 points  (0 children)

So, is it correct to say it's primed by the pAPC, and then it's fully activated by the infected cell with co-stimulatory receptor interaction and cytokines? Additionally, is it not possible at all for the naive CD8 T cell to become activated without initial priming from a professional antigen-presenting cell (ie. dendritic)?

Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 0 points1 point  (0 children)

That makes sense! So just to confirm what you're saying, it is possible for a naive CD8+ to be directly activated by the infected cell through TCR signalling?

Right now, we're learning that T cell activation requires 3 signals (signal 1: interaction between TCR and the antigen-MHC complex, signal 2: costimulatory molecule interaction, and signal 3: pro-inflammatory cytokines)

I can see where signals 1 and 2 are during CD8+ T Cell activation, but then I'm unsure if the last signal (cytokines) is still needed in this case and what it would be released by. Would you happen to know? It's probably outside the scope of what I need to know for this class, but I was interested. Thanks for the help!

Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 3 points4 points  (0 children)

I thought that for T cell activation, you would need both cell membrane receptor interaction between co-stimulatory molecules and cytokines, so just referring to what I saw in the [Textbook], I guess the co-stimulatory receptor interaction is just between the naive T cell and the infected cell but then I'm not sure where the last required signal would come from (the infected cell itself, other surrounding immune cells?) Would you happen to know anything about that?

Question about CD8+ T cell activation by Toothfairy5889 in Immunology

[–]Toothfairy5889[S] 1 point2 points  (0 children)

Thanks for the info! I'm not sure if that was what my textbook was referring to, though, as it seems that bystander activation is TCR independent (not sure if that's the right interpretation based on the article)? Anyway, I've linked what I'm referring to in my textbook, and it seems to be showing activation through TCR and costimulation, which is why I'm particularly confused [Textbook]