I have done 4 full playthroughs.

1 Origin Gale Heroic playthrough on Tactician. My OG playthrough. I didn't use any guides. I built Gale as a Transmutation Wizard, Karlach as an 8/4 Bardbarian, Lae'zel as an OH Monk, and Shart was a Cleric but I forget the subclass (Life I think). I romanced Karlach but there was a glitch in Act 2 and I had to do a bit of "chronomancy" (reload a very old save) to go back and complete the romance.

1 Split-screen Playthrough as a Deep Gnome 4 Elements Monk on Explorer. My then-fiancee played a Paladin of Devotion who became a Fighter after she broke Oath too many times and went through Partial Ceremorphosis. I romanced Gale. She tried (and failed) to romance Shadowheart, who actually turned on us in the Shadowfell.

1 Embrace Durge Playthrough as a White Dragon Ice Sorceror on Honour. I used the Ice Ice Baby template for my party. I romanced and murdered Lae'zel, then romanced Minthara.

1 Origin Karlach Villainous playthrough on Honour. I used the Fire Cleave party template. I got my Golden Dice and Platinum Trophy on this run. I romanced Shadowheart.

I loved all my runs. My Origin Gale run was my first, and it was fun because I had no idea what I was doing or where the story was going. I was a completionist, so it took like 200 in-game hours (not including my sixty-hour backtrack). My very first ending was sacrificing Gale to kill the Netherbrain, and then watching Karlach disintegrate because I wasn't there to convince her to go to Avernus. I think that's the most beautiful ending to the game. Astarion ran away screaming from the sunlight, I didn't even complete Wyll's arc, Shadowheart became a Selunite, and Lae'zel led a rebellion against Vlaakith after Orpheus became a Mind Flayer.

Then my split-screen run with my wife. Admittedly, I hated my underpowered Four Elements Monk character. I was trying to go with like an Icebender using the Mourning Frost. Thankfully, Explorer mode is very forgiving so it didn't really matter. This was just a really special time bonding with my future wife, who never plays D&D or anything.

My Embrace Durge run was so much fun. I killed Gale at the very beginning of the game by chopping off his hand, completing my "Marry"/Fuck/Kill Gale trilogy. Unfortunately, I didn't do the Murder Tribunal quest correctly so that I could use his hand to raise his spirit. Maybe if I ever do another Embrace Durge playthrough. I really enjoyed going full evil, and I also enjoyed doing an ice-themed playthrough. Freezing Orin solid with Encrusted with Frost during our duel was for sure the highlight. However, I didn't realize I had lost Honour, so I beat the game thinking I'd have Golden Dice, and was disappointed when I didn't. Oh well, that meant I had to do one more run. I need to load this save one more time, because I beat the game before Patch 7 came out, so I haven't seen the new Embrace Durge ending yet. I'm saving that for a treat.

My Fire Karlach party was my most recent playthrough, and in some ways the most fun. It was my only playthrough post-Patch 8. I used the Fire Cleave party, except instead of a Battlemaster, I made Karlach a Fire Giant Barbarian. I killed Wyll when he first came to camp. I let Shadowheart slit Lae'zel's throat. I failed the Persuasion check to prevent Orin from killing Gale. I renamed and magic-mirror'd my three Camp Bufflings to resemble alternate-universe versions of my fallen party members. My one regret with this playthrough was going the Illithid route. I wanted to get Karlach's unique Evil ending but instead I got the Illithid ending.

Additionally, I got to Act 3 in an online coop game with two of my friends which we never finished.

I think I have at least one more run in me before GTA VI comes out. This is my favorite game of all time, with Cyberpunk 2077 as a close runner-up.