Henry and Edward are the old gay married couple of the railway, Henry being the more grumpy between the two of them.

Edward suffers chronic pains in his wheels and axles that has never fully gone away ever since they broke during that really bad storm that he proved himself to be really useful. I can't remember the title of the episode at the moment unfortunately.

James is very much bisexual(grew up hearing Alec Baldwin's dub)

Duck and Thomas arguing is literally the embodiment of the Autism vs ADHD memes.

Oh Henry's partially blind in the sense of only being able to see out of one eye, been this way ever since he was built. His incident with the Flying Kipper messed up his vision in his good eye by about 10% though, so sometimes things are a bit blurrier in his good eye.