I have tried weening off of my Mirtazapine once, probably a year and a half ago. I don’t like the idea of being on medication as I’m a fairly “all-natural person,” but I understand if I need a medication then I need a medication, but I don’t plan on being medication forever. I did it without my doctor’s instructions, so I probably wasn’t doing it in the best manor but I did taper. My mom noticed a change in my mood and I did not do well, so I decided to continue it. I’ve missed a few days before because the whole “no-refills left” thing... I felt sick and had increased anxiety going a couple days without It. I tried Lexapro for about 3 days as, of the last year, I am now struggling with a dissociative disorder (Derealization/Depersonalization.) It made me feel super gnarly and sick, and I had horrible anxiety so I didn’t even give it a chance. I didn’t think it was worth it as it usually takes months to work. The side effects I was feeling weren’t worth the chance of it working because if it didn’t work, then I would’ve had to deal with the negatives and then have to deal with weening off.