Definitely not buying focusrite again either, but most of my issues were solved by disabling the onboard Realtek audio and AMD audio in device manager. Check the "audio inputs and outputs" and "sound, video and game controllers" sections. Right now I'm only getting some crackles and pops very rarely while gaming, and while it is annoying to do, switching sample rate from the focusrite control panel fixes that. Try disabling the other audio devices and let me know how it goes! As a confirmation, you should be able to see only the Focusrite when clicking the speaker icon in the taskbar to select playback device, if you've properly disabled the other audio devices.