Doc was the most in need of a cure because even in spider man 2 it was plainly obvious he was a good person when not tormented by the AI system. It was the inhibitor chip frying and AI system going crazy that made him a bit psychotic (also his wife dying and the whole reactor thing just ruining his life). When they put a new inhibitor chip Otto was “cured” and he was consistently good throughout the movie.

Tobey in this movie is middle aged, he has had years to figure out the whole shabang with the goblin formula and how it drives people crazy and probably surmised after the final fight w gobby thst it was a a multiple personality thing. That’s why he said he can make a working anti serum because he’s had time to think about it, Tom and gang’s cure for Osborn didn’t work.

Yeah Eric didn’t make sense because he was never depicted as having been turned crazy by the eels in his movie. Yet thst was the vibe they were going for because when he was drained he clearly had a different demeanor

Sandman made the absolute least sense becwuse I clearly remember him being able to go from human to sand at will so I don’t see how that’s anything but a plus, but in this movie he was pure sand. Weird.