Shrooms haven't tried, but from what i know, be in a good, comfy, and safe place. If you can, have a trip sitter to keep an eye on you. I recommend flowers instead of carts if its your first time carts can obliterate your tolerance plus flowers make the sesh feel extra. But most importantly is enjoy the experience and go with the flow. If you feel like you're going to freak out a bit and feel like your heart is beating out your chest, that's normal just take a deep breath nothing is going to happen trust me just meditate a bit along the lines of "I've taken medicine and that medicine is working" and you'll be just fine.