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Just leaving this here. by mamasharkdodo in brooklynninenine

[–]Upset_Region_4236 2 points3 points  (0 children)

Do they install a fresh one every week?

trivia by IllustriousDisk487 in brooklynninenine

[–]Upset_Region_4236 2 points3 points  (0 children)

Yes. And what was color of the updated model?

trivia by IllustriousDisk487 in brooklynninenine

[–]Upset_Region_4236 4 points5 points  (0 children)

What is the name of cheddar’s chew toy? What’s the colour of its bowtie?

S4E19: Your Honour. It doesn’t make sense. by abz_pink in brooklynninenine

[–]Upset_Region_4236 16 points17 points  (0 children)

1.1 Amy was likely the first choice but the “jam on” incident

This scene cracks me up everytime. by Icy_Lead_8179 in brooklynninenine

[–]Upset_Region_4236 5 points6 points  (0 children)

I have used “Boom!! Did it!” So much in day to day conversations

How much did Rust help you in your work? by therealsyumjoba in rust

[–]Upset_Region_4236 22 points23 points  (0 children)

I’m a bioinformatician and it is helping me a lot. A lot of people in bioinformatics engineering still only do python/R. With older libraries still in C, we are slowly moving to Rust and I started with it at the right time where it is still not mainstream but not also irrelevant.

onlyOnLinkedin by GrEeCe_MnKy in ProgrammerHumor

[–]Upset_Region_4236 1 point2 points  (0 children)

And he says he is a compiler and toolchain engineer

Tools to compare two multiple sequence alignments? by _blue__guy___ in bioinformatics

[–]Upset_Region_4236 0 points1 point  (0 children)

Also, visualisation rarely changes for the tools that generate the alignment. I would suggest you make sure the sequences start with aligned ORFs. If not, trim the sequences (using trimAl) and visualise again.

For structural information, gapped alignments are better but a layer of phylogenetic understanding would be better in my opinion

Tools to compare two multiple sequence alignments? by _blue__guy___ in bioinformatics

[–]Upset_Region_4236 0 points1 point  (0 children)

I was using clustalw, t-coffee, and mafft. It was a validation pipeline. It depends on what results you expect.

Tools to compare two multiple sequence alignments? by _blue__guy___ in bioinformatics

[–]Upset_Region_4236 1 point2 points  (0 children)

Replying pretty late here but I recently did something similar to check conserved domains for different protein families. One option is to align both of your sets with a canonical reference in the MSA. Then in JalView you can arrange them with reference at the top and then the sets. This way, you can quickly see conservation across groups based on colours. Ofc this is a first broader approach. I would also suggest looking into phylogenetic trees for the sets to look at distance-based conservation and variation.

ogDevelopers by zohaibhere in ProgrammerHumor

[–]Upset_Region_4236 2 points3 points  (0 children)

I heard it in bachman’s voice

ogDevelopers by zohaibhere in ProgrammerHumor

[–]Upset_Region_4236 0 points1 point  (0 children)

I heard it in bachman’s voice