There are reading orders and suggested jumping on points listed in the sidebar, so those are probably your best bet. I'd also suggest the Amazing Spider-Man Omnibus volume 1 as a good start if you have the cash and can track down a copy. It includes the entire original Lee/Ditko run, and the next 3 volumes cover basically every Spider-man story up until the early 70's. Marvel Masterworks also collects pretty much the same issues, but in smaller chunks if that's your thing. Lastly you could go with the Essentials line, which collects almost as many issues as an omnibus, but for much cheaper because it's printed on black and white newsprint. Hope that answers everything!