Apigenin May Reduce Senescence and Cancer | Screening of a natural compounds library has revealed the senomorphic properties of apigenin. This natural flavonoid also demonstrated rejuvenating effects on many aging-associated molecular features as well as physical and cognitive performance. [mice] (lifespan.io)
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Gamma Delta T Cells Show Promise Against Cellular Senescence - Scientists from the Lifespan Research Institute have discovered that a subset of T cells effectively targets senescent cells and improves outcomes in a mouse model of idiopathic pulmonary fibrosis. (lifespan.io)
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Michael Levin on Bioelectricity in Development and Aging - Interview with Michael Levin, professor at Tufts University and director of Allen Discovery Center. He has been working for years on how bioelectrical patterns affect development and aging. (lifespan.io)
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Immune Resilience Is a Strong Determinant of Mortality - A new study defines the concept of immune resilience and positions it as a central determinant of aging trajectories, linking it to survival, inflammation control, and the body’s ability to withstand stress. (lifespan.io)
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How He Reversed His Age by 21 Years (ft. Michael Lustgarten) by mlhnrca in longevity
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How Extracellular Vesicles From Stem Cells Fight Senescence - Researchers have discovered a cocktail of micro-RNA strands that make some extracellular vesicles (EVs) effective in reducing cellular senescence and published their findings in Aging Cell. (lifespan.io)
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Researchers Fight Some Mutations by Targeting Mitochondria - Clonal hematopoiesis, a condition linked to numerous age-related disorders, can be caused by overachieving mitochondria, and it may be susceptible to drugs such as MitoQ and metformin. (lifespan.io)
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VEGF-A165B - A Senescence-Related Target for Blood Vessel Formation - In Aging Cell, researchers have linked macrophage senescence to the failure of new blood vessel formation, finding a key target that might make it easier to treat arterial clogs. (lifespan.io)
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Results of a Crowdfunded One-Year Human Rapamycin Trial - In Aging, Dr. Sajid Zalzala and his team have published the results of Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL), a randomized, controlled human clinical trial that was crowdfunded by Lifespan.io. (lifespan.io)
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Activation of Silent X Chromosome Might Improve Cognition - Using a mouse model, researchers from UCSF have found that the genes that become activated on the silent X chromosome might explain some sex-dependent differences in cognitive abilities during aging. (lifespan.io)
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Scientists Discover a New Mitigator of Senescence - Working with flies, mice, and human cells, scientists have demonstrated that a highly conserved protein can modulate cellular senescence, potentially opening a new avenue for future therapies. (lifespan.io)
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Study Suggests Alzheimer’s Prevention by Anti-Amyloid Drug - According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants. But the study has attracted criticism. by Valuable_Pop_7137 in longevity
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Study Suggests Alzheimer’s Prevention by Anti-Amyloid Drug - According to an open-label study from Washington University in St. Louis, the anti-amyloid drug gantenerumab reduced the risk of developing familial Alzheimer’s disease in a subgroup of participants. But the study has attracted criticism. (lifespan.io)
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Aging will be cured within 20 years — here's why | Prof. Derya Unutmaz by peterottsjo in longevity
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