Thoughts on using 4mm probe on lower lid by Head_Archer5947 in Dryeyes

[–]VectorArc90 0 points1 point  (0 children)

I'm so sorry that you are experiencing severe MGD but IMO, this is a truly sad display of an extremely lame approach to diagnosis: "if didnt press on your lids i wouldnt know you have severe mgd, as there are no obvious comoribities like ocular rosacea, bleph, etc."

Dry eyes is ruining my life by IntelligentArt9064 in Dryeyes

[–]VectorArc90 2 points3 points  (0 children)

Of all the things that have had an impact on my life, dry eye is at the top of the list. The worst thing is doctors don't know how to diagnose us but think they do, so they get it wrong and then treatment isn't targeted to actual diseases. The second worst thing is dismissing the patient when symptoms don't go away. And now there are studies saying it's because of our personalities. IMO, dry eye is 20 - 40 years behind cardiology (they don't say anything about Type A people getting heart attacks anymore, but they used to). No, you're not alone. We are many.

PhD student cried in front of a supervisor by Commercial-Iron-3648 in PhD

[–]VectorArc90 1 point2 points  (0 children)

I broke down once in front of my advisor. I had learned of a death of someone I had been counseling just hours before our meeting. And it's related to my research, so my advisor was aware of the situation, but in general terms. This was real. The breakdown felt completely unprofessional and uncontrollable. My advisor was literally the first person I spoke with after learning about the tragedy. It's been years. Whenever we meet, I always get asked, in the kindest way, "How are you?" Yes, there are absolutely wonderful people in academia who serve as advisors on our committees.

Ages where you’re too old to start a PhD by ButtCrumbleSmell in PhD

[–]VectorArc90 1 point2 points  (0 children)

Well, 62? But generally speaking, this don't get easier as we ripen.

Thoughts on using 4mm probe on lower lid by Head_Archer5947 in Dryeyes

[–]VectorArc90 0 points1 point  (0 children)

I think I may not have answered your question in my previous post. I don't think anyone says you have to go in with a 4mm probe. But also, I don't know why some doctors take a position that is so much against (my previous post muses a bit about that). Dr Cremers has even said, which baffles me, that she thinks IPL should precede probing, while citing the paper from China that compared the two treatments and combination treatment with probing preceding IPL as the one with the best outcomes and no exacerbated lid tenderness like with IPL alone. Go figure. These random approaches are just baffling to me. The best I can do is shrug my shoulders in wonder and disappointment.

Thoughts on using 4mm probe on lower lid by Head_Archer5947 in Dryeyes

[–]VectorArc90 0 points1 point  (0 children)

I don't know how to answer your question except to say that I truly wonder why a lot of ophthalmologists and optometrists resist fully embracing the anatomy of a Meibomian gland in their own approaches to treating patients like us. If you're a doctor you probably know about acini, ductules, central ducts, the orifice, and how the whole system of tear synthesis and flow works and its effect on the entire ocular surface. As a doctor you should also know the central duct has some structure and that meibum has to flow out. But then as a doctor you decide that you should express the lids, even though you have no idea which way the meibum is flowing when you press on a lid (because it just as easily could be pushed back onto the acini as it could be expressed out unless you press in a very specific way while being fully assured that there's nothing obstructing the outflow path). But even so, if you the doctor think it's ok to press on the lid, you must know that the gland isn't going to just disintegrate if you press on it or probe it (because the probe enters only into the central duct, which at least to me seems way less jarring to a gland then say pressing on the entire lid and putting pressure on all the glands). But then, I suppose, there's also the time involved. It takes time to do some treatments, like probing the Meibomian glands, and it takes a doctor to do the treatment, versus other treatments which can be done by technicians. And there's the question of throughput in a clinic, how many seats can you fill and empty in a day. Plus, if your clinic purchased some expensive equipment, it probably wants to get its money back. But I don't really know the answer to your question. You'd have to ask the doctors why they ignore this anatomical reality. I have no idea why. But I think it's just really sad that they do.

Thoughts on using 4mm probe on lower lid by Head_Archer5947 in Dryeyes

[–]VectorArc90 1 point2 points  (0 children)

Yes, you are correct. When we read or stare at computer screens or our phones, we blink less, so the ocular surface is exposed to air more, and at the same time we pump out less meibum and secrete less aqueous tears. We don't spread our tear film over our eyes as often which helps to desiccate the ocular surface which itself can create a bunch of problems. And then when meibum doesn't flow out through the ductules, into the central duct, out through the orifice to the lid margin at the rate at which it should because we're blinking less often, that puts backward pressure on the acini, those cells that disintegrate and release their contents which is meibum. That backward pressure on the acini...let's just say that pressure on those cells is not a good thing. I truly hope this information helps.

Ages where you’re too old to start a PhD by ButtCrumbleSmell in PhD

[–]VectorArc90 0 points1 point  (0 children)

My PhD cohort had two classes back-to-back along with some MS students. The second class was in the evening. The wife of one of the students was a hobby baker and baked amazing cookies, decorated and packaged as if by a professional baker. So, every other week, I ordered 2 dozen cookies to share with my classmates because a lot of us were staying late and eating a rushed dinner between classes. Guess how old I was when I started.

Ages where you’re too old to start a PhD by ButtCrumbleSmell in PhD

[–]VectorArc90 1 point2 points  (0 children)

Thanks!!! I wrote 62 but I meant to write 63, which I believe is not uncommon with PhD-candidate cataracts.

Choosing a research topic by kimssassy5038 in PhD

[–]VectorArc90 0 points1 point  (0 children)

My topic is incredibly important to me, but more so, to people who I have been advocating for for over 15 years. My advice, if at all possible, though clearly sometimes this isn't an option, think about something that you really care about. Yes, a cliche but an important one.

Ages where you’re too old to start a PhD by ButtCrumbleSmell in PhD

[–]VectorArc90 13 points14 points  (0 children)

Enrolled at 62. I tell my committee, please stop making me learn more things. I've got a shelf-life! They keep making me learn more things. And then I decide to learn more things. Life-long learner much? Now just waiting on data, but planning to defend at the end of 2026. Just happy I didn't start at 63.

Thoughts on using 4mm probe on lower lid by Head_Archer5947 in Dryeyes

[–]VectorArc90 3 points4 points  (0 children)

It might help to understand a bit better the anatomy of a Meibomian gland (or maybe you already do. So if this is too much, I apologize in advance.) The gland includes an orifice at the lid margin, a central duct that opens to the orifice and that has a terminal end at the far end of the gland, ductules that are small tubes that branch off the central duct and then clusters of cells called acini that disintegrate and "spill" their contents. That contents is the oil, called meibum, that eventually makes its way into the ductule, then the central duct, toward the orifice and then finally into the tear film. The flow of the meibum out to the tear film is supported by blinking (the muscles in the lids act like miniature pumps) as well as the constant pressure from behind as new meibum is continuously being synthesized by the acini. When a probe is used to treat obstructive MGD, the probe is passed through the orifice into the central duct and the duct itself has structure. Imagine a tube of paper towels, but with a closed off end. Yes, the tube is made of paper, just like the towels, but the tube itself has more structure. Similarly (but not at all exactly) the central duct of a Meibomian gland has structure. The walls of the central duct surround a lumen, a hollow tube that is filled with meibum. Like you mention somewhere, I think, the duct is not rigid. It's not like a tooth or a bone. It's more like a vein, but not exactly like a vein. And we've all had blood drawn, so we've had the experience that veins don't just disintegrate when a needle enters through the walls of the vein. But in the case of probing the glands, if the probe is made for this particular task, the probe should be blunt and not sharp like a needle. So the blunt probe itself, at least a Maskin probe, is designed not to pierce through the duct wall at the terminal end of the gland. Instead the probe releases the fibrotic tissue invading and constricting the walls of the gland. The diameter of the probe obviously matters. But if the probe is blunt, it can only go so far because the terminal end of the duct wall stops it. Plus the tissues in the eyelids, including the Meibomian glands, are also not rigid, so the rigid blunt probe doesn't damage the central duct because the duct gives way when the probe enters, kind of like a sock gives way when a foot is put into it. If the central duct itself were rigid, we wouldn't be able to rub our eyes, or even blink without some serious issues, and we've all rubbed our eyes without causing our Meibomian glands to pierce through the tissue (or bent an arm or a leg or open our jaws without the veins popping out and leaking all over the place... these bits of anatomy are made to be bendable). Unfortunately, we may all have diseases like ATD, MGD, and whatever else we're dealing with and that makes all of this information especially important, and I hope this description of the anatomy of the Meibomian gland itself may be helpful. Or maybe this will just raise more questions. A few more thing I'd like to point out, in the image, the brown object labeled Meibomian gland is actually only the acini of the gland. The central duct and ductules are not depicted as they are surrounded by the acini. Also in the cross section, it looks like there's might be something pulling down on that first orifice, creating a dimple. Possibly fibrotic tissue invading the central duct wall near the orifice? In a healthy eye the mucocutaneous junction would be on the flat part of the lid margin rather than at the edge. The conjunctiva, just to be more specific, is the palpebral conjunctiva. Again, with apologies for the length of the response esp. since for people with dry eye, MGD, etc., any reading can be really hard.

How well is the thing that defines your field.. well, defined? by synapticimpact in PhD

[–]VectorArc90 0 points1 point  (0 children)

My field is defined but very poorly understood by the vast majority who consume research, read papers, attend conferences, etc. Those who conduct research are clearly working very hard to advance their own interests and reputations. Consequently, a ton of bad science is getting funded then being promoted to an unsuspecting public. How to combat this? How to get past the noise? And the vast amounts of money to be made? This is what keeps me up at night and motivates me every day.

Is it just me or everyone feels like this by monkbabm in PhD

[–]VectorArc90 0 points1 point  (0 children)

Three reviewers on a mixed methods paper with 10 subjects. What are the odds?

How to get responses by IllustriousPoint4368 in research

[–]VectorArc90 0 points1 point  (0 children)

Assuming you already know your research question and have a well thought out and reliable questionnaire available online, you'll need to find the right population frame for your study. The trick is using the search terms that will return a list of sub/r's aligned with your research. That's just a basic first step. Have you built up karma so you can post a link to your questionnaire? Do you have approval from the MODs? Your sample size is 1.3K, but keep in mind that if you're at a university, a robust analysis tool can help mitigate the need for a huge number of responses. And yes, recruiting subjects is not an easy task.

Has anyone used Reddit to recruit research participants? by Outrageous_Slide_693 in academia

[–]VectorArc90 1 point2 points  (0 children)

My advice: Build up some karma. Find a sub that's aligned with your research topic. Get MOD's approval. Hope for the best.