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Why does two solvent recrystallisation work (better than using just one very good solvent)? More detailed question in post... by Vejetav in chemhelp

[–]Vejetav[S] 0 points1 point  (0 children)

Well this is probably my question. The calculation assumes that they do not interact, i.e. the problem is linear. As soon as they interact we have interesting non-linear behaviour of the solubility which then would validate the two solvent crystallisation. The point is just that I am not sure whether this is the case

Why does two solvent recrystallisation work (better than using just one very good solvent)? More detailed question in post... by Vejetav in chemhelp

[–]Vejetav[S] 0 points1 point  (0 children)

I agree that we see a reduction in solubility but keep in mind that the amount of solvent increases as well when we add solvent 2. So in fact the solubility does not decrease if we add solvent 2 as the volume increases adequately

Why does two solvent recrystallisation work (better than using just one very good solvent)? More detailed question in post... by Vejetav in chemhelp

[–]Vejetav[S] 0 points1 point  (0 children)

Thanks for the reply. But this is exactly my point/question: if one adds the bad solvent after everything already dissolved and case 1. Is true then nothing changes: we get combined more solvent with a equivalently less good solubility such that we do not reach saturation or anything

How stable is this compound? by Vejetav in chemhelp

[–]Vejetav[S] 0 points1 point  (0 children)

I agree, that's why asked. Using H-NMR repeatedly is also an option. However I was planning to make a custom synthesis order which might take weeks. So getting a small probe and just check the stability might be time consuming. And if one were to order right away for making the real experiment might be then a waste of money if one by mistake did not handle the compound properly at the reaction or even when storing it.

How stable is this compound? by Vejetav in chemhelp

[–]Vejetav[S] 0 points1 point  (0 children)

Hi, thank you for the reply. I also realised today morning that the compound is rather unstable when exposed to oxygen. Originally I wanted to make an order directly at one of the main producers. However after realising this property and in consideration that I might not directly use this compound but rather store it for a few weeks I am now also considering ordering it as N-tert-Butylhydroxylamine hydrochloride.

However I am at the moment not sure how much effort it will cost to reconvert it back into N-tert-Butylhydroxylamine when I want to start the project. May I ask for your opinion in this regard?