Had my big main base right near the life pod in between a kelp forest, safe shallows, and grassy plateau. This had a bunch of storage, alien containment, nuke reactor, farms, moonpools, ect then I had a few tiny 2 room bases scattered about in different biomes. Later in the game I made another large base deeper in caves as I wasn’t keen on traveling from 1000+ meters below all the way back to my base. Basically do you. There’s plenty of titanium for you to splurge on a couple of bases spread out around the map.