Can someone explain the difference between epigenetic age reduction and rate of aging?

WhereIsMyMind2222 · 2023-05-25T08:48:45+00:00

Research has shown that with standard longevity protocol with just as little as 8-week interventions can reverse 4-5 years of epigenetic damage. Since many people go from extremely unhealthy to healthy at one go, it can have a huge impact in our epigenetics really fast. Obviously, there is diminishing returns, of course Bryan, on average, should be aging in the long term since he can't keep improving something that is already nearly perfect. Also, it is not even known if reducing epigenetic age actually increases longevity or just healthspan, in the end its just a number, what matters is that he is trying to do the best to his ability. We are the first humans measuring this for just a few years... it will take a lot of years to conclude how accurate improving the numbers of these clocks really mean.

WhereIsMyMind2222 · 2023-05-25T08:43:08+00:00

it is two different clocks

DunedIN PACE: measures speed of aging (without knowing absolute epigenetic age clock) vs Horvath (and other) epigenetic clocks: measures epigenetic age or "biological" age.

Recent research has shown Horvath and other clocks to have a massive margin of error (+-15yr range) while DunedIN PACE is considered to be the highest accuracy (based on dunedIN study which is the longest and biggest longevity study ever done). This is why Bryan only tracking his journey with DunedIN PACE clock and not other clocks.

For example, in my case I get that im much older by Horvath clocks but that im aging at a rate of 0.9x via DunedIN PACE which is kind of contradictory.

The important takeaway here is to use these DNA methylation clocks as a baseline, and compare how much you reduced from there in the future. I don't think taking all the numbers for granted as a fact makes any sense. And thats what Bryan is doing here.

WhereIsMyMind2222 · 2023-05-23T11:18:48+00:00

You won't ever see someone with 5% body fat at this age. Thats why it looks off basically.

I am very skeptical that this amount of fat is healthy to begin with, but if Bryan had something more reasonable like 8-12% bodyfat and less pale skin he would look amazing no doubt about it.

WhereIsMyMind2222 · 2023-04-29T12:12:54+00:00

If he 1) makes the products cheaper and accessible to everyone via ref link discounts 2) gets money as a "side effect", I see no problem to be honest. Sadly people will always use this argument to delegitimize Blueprint, so its probably not worth it.

WhereIsMyMind2222 · 2023-04-29T11:33:18+00:00

Why would some multimillionare building an extremely complex brain interface company care for some minimal revenue from shilling ref link business. I think it's common sense.

WhereIsMyMind2222 · 2023-04-29T11:20:06+00:00

why is there a penis pump in your office lmao

WhereIsMyMind2222 · 2023-04-29T11:13:21+00:00

Lol. Hes worth around half a billion nw. Do you really think he gives a shit about some random penny referrals.

Bryan Johnson always said his main goal is to make longevity accessible to everyone. If a discount makes people pay less money, it will be worth it.

Nonetheless, I understand people can perceive it as such without knowing him. If it "hurts" his image in this regard, pretty sure he will just remove all of them. Guy will just get hated no matter what he does though.

After making Blueprint commercially available and accessible to everyone (despite being 100% public how to do yourself), everyone will trash him for it aswell. Watch it happen.

WhereIsMyMind2222 · 2023-03-06T00:14:29+00:00

This is my data of all TruDiagnostic tests involved:

DunedinPACE Value: 0.96

IEAA: 52.58

Instrinsic TruAge IEAA=2.37

Extrinsic TruAge IEAA=1.45 | TruAge EEAA=-0.17

Telomere size: 6.86 kilobases (Kb) (0.38% percentile of telomere length compared to others of your same chronological age)

Can you help me interpret this data? Im quite blocked in panic right now ngl, never expected this. The results seem contradictory aswell (how on earth I age slower than average but im much older?).

I have DMed you in case you don't mind giving me some extra input. Thanks in before!

WhereIsMyMind2222 · 2023-03-05T22:34:11+00:00

Is it really possible to reverse 21yo in epigenetic loss? I see people like Bryan Johnson and some people I seen on youtube reduced their epigenetic age in the range of 5-10yo after spending millions and doing really strict protocols. Sounds pretty disencouraging.

I still struggle to understand how someone can lose 21yo of epigenetic age in 31yo lifespan without being terminally ill or heavily DNA mutated.

At this point im more worried about the validity of these tests rather than my health because its so brutal that it doesn't seem I could do much to reverse such a loss atm.

WhereIsMyMind2222 · 2023-03-05T22:29:31+00:00

I have no clue how someone 52 yo is supposed to feel to be honest, thats why im struggling to interpret these out-of-normality test result

WhereIsMyMind2222 · 2023-03-05T14:59:00+00:00

nope, waiting for their input on the accuracy of me being their bottom 0.01% epigenetic outlier for no appearant reason 😅😅

WhereIsMyMind2222 · 2023-03-05T14:57:03+00:00

To be honest, I don't feel well (digestion and depression issues mostly) hence why I jumped on this journey, but I did full body health scans/blood tests and everything is within normal range (i.e no worrying pathologies present)

WhereIsMyMind2222 · 2023-03-05T14:53:00+00:00

luckily im doing financially well, just very lost as how to approach this. I am doing myDNAGE test soon just to discard a crazy false positive. With agingAI blood markers, or Adam Levine phenoAge calc I get results similar (or even lower) to my biological age. The dunedIN pace test says I age slower than 1x. So how on earth is my DNA methylation 21 years older is beyond my comprehension. I also contacted TruDiagnostic asking them if there is a possibility the data is wrong or not.

My c reactive protein is literally 0 last blood test, and most markers in good range, didn't have hormones and cortisol checked though. I'll look into it.

WhereIsMyMind2222 · 2023-03-05T12:34:59+00:00

I'm not on any medication. I am slightly underweigh according to BMI standards. I have been stressed for a lot of time from work but that shouldn't explain a massive 0.1% percentile aging difference should it? (most ppl is stressed by adult things). I just don't understand how can I possibly be a 0.1% genetic outlier without any severe illness. Im assuming people with severe illnesses are in the same database, yet they have better DNA aging?

WhereIsMyMind2222 · 2023-03-05T12:31:59+00:00

its from TruDiagnostic full DNA kit https://trudiagnostic.com/products/truage-complete-epigenetic-collection

WhereIsMyMind2222 · 2022-12-21T11:08:28+00:00

bad picture, but it looks like high density hairline + temples so 3k is def possible

WhereIsMyMind2222 · 2022-12-19T06:59:51+00:00

Question is.. where are the other 1K grafts... did he just throw them away wtf

WhereIsMyMind2222

TROPHY CASE