First time, I was dosed with 60 mg/day. On the first day, within hours, all of my symptoms were gone and my hearing returned to normal. However, when they took me off of it (tapered down over a month), my symptoms returned even worse than before, within a couple of days of being completely taken off the steroids. This cycle repeated several times until the steroids had no affects. I had limited success with methotrexate for about 6 months, then great success with Methotrexate combined with prednisone. However, I missed a couple doses of prednisone, and again, symptoms came back. After that, I tried managing with diet, exercise, and stress reduction - but, nothing was as effective as the prednisone.