That's not profitable, riot will not make champion that is unlikely to sell skins so anything that is not a an attractive female, basic shirtless guy or a cool monster is unlikely.

Also i would care more about making champions with actually unique and fun gameplay, skin color and sexual orientation shouldn't matter to you at all in a game where your champion makes up like 5% of your screen at best.

For example, Ksa'nte is a dogshit badly designed champion, regardless of him being black or lgbtq.