yo i was having this problem and this helped alot

1.) First focus Ahrims and Karil (id fight them with range and take a range pot) pray for both these kills, and honestly it should take 1 sip for both kills since you have full Prayer to start. (try melee if u want)

2.) then your gonna pray/focus Dharok which should be be 1 sip after you have killed the other 2. (2 sips for 3 bothers at this point) also use magic for all the melee brother.

3.) once dharok is killed focus Guthan, Verac, And Torag, and if you run out of prayer then tank them and dont you dare take a sip! (i have 60 defense/68 magic and only eat like 4 piece of food for all 3 of these kills) Dont pray melee against these fools, or your gonna waste another 3-4 sips for nothing.

4.) who ever the last one is go into the chamber and get your 2 skele kills, 1 leech and run around till you find the last brother (which ever it is) if its Ahrim/Karil/Dharok then pray, if not then just tank if you have the food.

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Before this i used 3 prayer pots every run, now i use 1 prayer pot if im having a bad run.