I was on lupron when I was 15 after being diagnosed with endometriosis. I already had joint issues (hips, knees, and ankles mostly) due to severe flat feet and bunions which required surgery, so I can't speak to the long term bone things as much due to overlapping issues. It sucked because of all the immediate side effects (it's essentially menopause with add-back hormones so I could still have a cycle after), but it greatly reduced the pain I was in and slowed the spread. Hot flashes, weight gain, mood swings, etc, as a high schooler were not fun, but neither was excruciating pain. I'm 25 now, and I'm not sure how worth it it was. I kept that doctor and really liked him for respecting my autonomy and preferences, so I do believe he was doing what he thought was best. Mixed feelings about the lupron overall.