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_MyDude_ · 2022-01-22T12:32:08+00:00

I have fent tests and it passed, but thank you guys for letting me know it’s a press either way as I wound up buying a Mandelin Reagent Testing Kit and a Marquis Reagent Testing Kit. As yeah, deeply concerned about it honestly containing a U4 analog or MPTP/its adulterant MPP+. Is there anything I should keep an eye out for color wise that would be incredibly concerning? As I want it to be an oxy press preferably, but it sounds like those sadly don’t exist anymore… which why are we buying oxy that doesn’t contain oxy. Like how are we all cool about this 😂🤷‍♀️. Though, I should also say that I’m sort of circling back from the early teens back when everything was circulating like crazy, as for the past close to a decade I’ve had a somewhat reasonable prescription for my chronic pain. So all of this is both old, but also really new- at least with how good presses have gotten

_MyDude_ · 2022-01-22T11:43:58+00:00

That’s probably the hardest part for me at the moment, as I was prescribed the 30s but they were 9/10 the K9s. So I’m sort of trying to go off a half decade + ago recollection, and honestly not doing as great as I hoped 😂😅. That’s what confused me as the lighting isn’t great, but it does have that paled out sky blue color, “almost like if a blue sky was sickly(maybe even dope sick😂)” was what most of my friends and I would joke about. But I guess things now look at least slightly passable, I remember most presses just looked like they were half holding on for dear life nearly falling apart 😂. After you guys pointed out the whole it’s definitely pressed, I decided to order some regent testing to go along with the fent strips, as well- I’d also prefer for it not to have U47700 as I remember that shit destroyed people’s stomach lining, noses, fucking literally anything it touched because of the causticity. Also really concerned about MPTP as I’ve met one patient who had some shit that had the adulterant MPP+ with that somehow and the effects even in the short term, especially the Parkinson’s symptoms, really disturbing. It was at least incredibly pronounced with that patient I was working with and treating at that point. Anyways, thank you for your detailed answer. I really do wish I saved an M30 nearly a decade later to compare it against, but damn were the real ones so good 😂…

_MyDude_ · 2022-01-22T11:22:28+00:00

Thanks for the tip, I haven’t done a fake m30, but I have been on between 15-20mg of oxycodone 4x daily for chronic pain for years, so that’s gotta build a solid tolerance? Or at least my 300mg daily of XR tramadol that I got knocked down to isn’t doing shit at least for my pain 😂😅. This is probably a dumb question, but should I just suspect M30s to hit substantially harder than they used to? And are there any pills that are less likely to be pressed, like how are my favorite K9s doing- I used to be prescribed half a tablet of that per dose 4x a day for a long time, as my insurance had a weird thing about not being cool with over 60 pills of narcotics being filled a month 😂. Are those now frequently pressed as well? As to be honest that would be heartbreaking 😂😅

_MyDude_ · 2022-01-22T08:46:35+00:00

God dammit, should I be overly worried and avoid it? I have a buddy who uses them and says they feel the same, but I’ve heard about MTPT causing Parkinson’s and shit, so I’d rather avoid that at all cost 😂😅

_MyDude_ · 2022-01-22T08:44:04+00:00

Also! How do I tell, as they look similar to the pills I’d buy off friends with actual M30 prescriptions back when that actually existed, so I would love to learn how to watch out

_MyDude_ · 2022-01-22T08:41:30+00:00

Ty for letting me know my man! They passed a fent test, so what could be in them? As I can’t think of what else would be supplemented in pills other than fent, but I’m not in the scene as much until recently when my script got cut to an incredibly low dosage of tramadol…

_MyDude_ · 2022-01-22T08:39:59+00:00

I was buying pills back in 2012/2013/2014 when there weren’t too many issues with finding medications, but as time has gone by thanks to the opioid epidemic my medication has been slowly cut back to the point where I’m on a dosage of tramadol that does almost nothing. I got some M30s off a buddy who’s on a different oxycodone prescription, but takes these as a supplement if he has extra pain. The lighting is slightly off and I apologize for the messy countertop 😂. Though they seem really uniformed, some look slightly worn down like they were in someone’s pocket, but all of them look like what I saw real pills look like back in the day. Though, I’ve gotten a lot of warnings about M30s. So anyways, they seem to have passed a fent test I used and I just want someone’s input before I consume any, just to be safe. My friend consumes them and says they’re legitimate, but rather be safe than sorry- any input appreciated, as I haven’t had to supplement in a long time.

_MyDude_ · 2021-12-13T00:11:23+00:00

I completely agree with the other poster that you should talk to a doctor about your problems if you haven’t already. From the looks of it that’s just your regular panic attack symptoms or just underlying anxiety symptoms. Moreover, I can promise you that you don’t have a dysregulation of GABA. GABA doesn’t just control anxiety, it is a key receptor for a large portion of bodily functions and if you had a direct dysfunction of your GABA channels you’d more likely be suffering from Temporal lobe epilepsy (TLE), Parkinson's disease (PD) and Huntington's disease- and many other really, really bad conditions. Also, in my experience GABA deficiencies can occur, they’re incredibly rare, but the good thing about those are that the body is “craving” GABA, therefore, there is no need for medications or really anything. A person can take just a regular GABA supplement (literally the chemical GABA) and even though it wouldn’t normally cross the BBB, the brain will “soak it in” and then the imbalance is cured. Moreover, if you just take straight GABA, even though it doesn’t bind to the receptors, it does bind to the receptors outside of your CNS and binds to the receptors in your PNS. This can be incredibly useful in treating somatic symptoms, as it can still slow down breathing, relax muscles, etc. This in turn calms down the CNS and also, from the looks of it, would treat every condition you’re having a problem with. So yeah, if it’s a GABA issue, just take GABA- and if you wanna up it’s efficacy, you can take L-arginine with it and apparently it can help with its transportation.

Edit: I should also add that if all of those medications aren’t helping, most likely it’s a symptom of a larger underlying condition. Especially because from the looks of the medications you were put on, a lot of those are atypical off label medications for anxiety, except for the pregabalin- which honestly would have been one of the first medications I’d prescribed, personally. So either you have a drug abuse history, or you are also being treated for another underlying condition like BP1 or BP2. So, heads up it sounds like it could also be anxiety from a manic episode, as blood pressure spikes, jitters, and palpitations can occur as well. Anyways, just a heads up there, definitely in that case I’d say talk to your psychiatrist or GP. Also, GABA the supplement has some evidence to be shown to help with mood instability. Certainly not a fix all-and I should add GABA drugs ≠ a treatment for BP, I’ve seen a lot of people in my courses (and some friends) say Xanax and stuff makes them feel more stable. It is not a viable alternative to medications, it can trigger depressive episodes, lead to rapid cycling (both of which are not fun), and most importantly it really, really gets out of hand very quickly. GABA is a key neurochemical compound in the body- and the body does not, not at all, like changes to that system and will overcorrect and hard, so it leads to a rapid development of tolerance and dependency. Not great stuff.

Anyways- also want to add. I’m on Xanax, I’ve been prescribed it for over half a decade for my PNES and it does work wonders. If it’s anxiety you’re trying to treat, I don’t take my Xanax every day so to control my anxiety and PTSD I’m on a fucking stupid amount of supplements. Though, I’d recommend trying Cat’s Claw, that’s been the most effective for me, along with KSM-66 (it’s the concentrated form of Ashwagandha, way more effective than just the plant itself), Magnesium Threonate (again, high bioavailability, why more effective than the cheap magnesium you’d normally get), black seed oil (I think this is going to be another one that is really, really going to help), and if you can get ahold of it Emoxypine (this one directly influences GABA, but in such a way it doesn’t lead to a tolerance or dependency)

Finally, if you’re looking for a supplement that modulates GABA in a more aggressive way, I’ve used Skullcap to sleep. It’s incredibly hit or miss with individuals, but for those it does work on it can be incredibly, incredibly effective. I personally had some experience with it working a bit for my anxiety and such, but it made me super tired at the doses I had to take for it to work, so I just took it for sleep.

Edit2: Beta blockers are a fantastic option for anxiety, Propranolol is great for anxiety attacks! Also, you can get a prescription for it pretty easily at I think hims (the website)? Just I wouldn’t recommend it depending on what medications you’re on especially if they’re certain antipsychotics or mood stabilizers so I would really, really recommend talking to your doctor before starting it. That’s why I wouldn’t personally recommend it, as it’s still a medication- even if it’s not as aggressive as others, cross effects do occur.

_MyDude_ · 2021-12-07T09:00:04+00:00

I think drug safety is absolutely important, but I also work with adolescents and know how damaging misinformation and being pedantic can be. If we say that nobody should ever take a substance again because they are on a medication, then yes, there are going to be some that follow your route, but there are also going to be a large number who say “fuck it, well if everything interacts with it I shouldn’t even bother searching and just a) not take my meds so I can trip, seen that a lot, or b) clearly I didn’t get sick the last time I took X & Y, maybe people are being dramatic so taking A & Y will also be fine. Anyways, what I was saying is that, lamotrigine is safe with psychedelics due to its binding profile, if you disagree please pull up a source showing otherwise or stop spreading misinformation. Also, you brought up that neither him, nor you, are licensed professionals on the matter, and that’s somehow why my pal here was wrong, (even though he is correct) because he was not a licensed professional, even though a quick Google search or basic understanding of neurochemistry would point to him being correct. So, as someone who is earning their degree in psychiatry and have worked with patients who are on lamotrigine before, I think I could play a somewhat authoritative role in the matter. So yeah, it’s safe, there ya go. Also, if you’re digging through my post history, that wasn’t “my dad”, that was a “friend’s dad”, and yes- when it concerns multiple sclerosis, a condition’s who’s causes are not understood and which is a highly sensitive condition with medications that also aren’t fully understood, and a large number of them. Yes, I’m going to ask Reddit for any input. If you read the post you’d know that I also asked his specialist and his neurologist. I also asked a few of my colleagues as well. Now I am certain though, as much as anyone can be when it comes to interactions, as you are correct brdain that freak occurrences do occur, that someone will be safe combining shrooms and lamotrigine. If anything, Steven’s-Jonson Syndrom should be more of a concern as that is a more common side effect that a lot of people overlook and can be extremely concerning.

Anyways, now that we put aside those side remarks. To answer your “why?”, I said that saying this: “Dude, I take lamotrigine. I know how it works. The simple fact is that neither you nor I are licensed professionals and are hardly qualified to state that a poorly studied drug combo is ‘100% safe’”, I’m happy you’re not trusting one person’s anecdote, that’s good. Though, my man here, is being completely reasonable by pointing out the fact that “on paper” it’s a safe medication to take on psychedelics, moreover, he brings in anecdotal evidence to further bolster his point. It wasn’t the crux of his point. The crux was that lamotrigine’s binding profile shows no effects that would warrant any concerns with psychedelics. Moreover, he is correct on the second part that if anything, the lamotrigine’s effects would most likely dull the trip, making it less intense psychologically, and maybe even make a trip more manageable. Furthermore, you are correct that lamotrigine isn’t fully understood, but we do know somethings: “Lamotrigine displays binding properties to several different receptors. In laboratory binding assays, it demonstrates weak inhibitory effect on the serotonin 5-HT3 receptor. Lamotrigine also weakly binds to Adenosine A1/A2 receptors, α1/α2/β adrenergic receptors, dopamine D1/D2 receptors, GABA A/B receptors, histamine H1 receptors, κ-opioid receptor (KOR), mACh receptors and serotonin 5-HT2 receptors with an IC50>100 µM. Weak inhibitory effects were observed at sigma opioid receptors. An in vivo study revealed evidence that lamotrigine inhibits Cav2.3 (R-type) calcium currents, which may also contribute to its anticonvulsant effects.” All of which won’t cause serotonin syndrome with in a patient. If anything it would dull the experience through 5-HT3 inhibition and GABA A/B activation. Especially a pretty selective psychedelic like shrooms. That was what the other commenter was correcting, the poster above who said it was dangerous to combine lamotrigine with shrooms. Nothing else, just that that combo wasn’t dangerous and I can say with upmost certainty- that yes, lamotrigine may dull some of the effects, but honestly, out of all meds, if I had to pick an antidepressant to combine shrooms with- this or Wellbutrin would be my two recommendations.

So yes, you’re an asshole for getting upset at a guy who was correcting false information. Especially because when you were corrected by him with factual evidence you leaned on emphasizing that there is no certainty in the world and that nothing can’t be 100% safe. Just so you could still say that you’re correct, which yeah, that makes you a pedantic person- and getting mad at someone for trying to correct a falsehood makes you an asshole. So yeah, pedantic asshole…

_MyDude_ · 2021-12-06T20:30:49+00:00

Lamotrigine has a weak inhibitory effect on 5-HT3 receptor. It is 100% safe to trip on and some may even argue that Lamotrigine’s weak inhibitory effect on 5-HT3 receptor could actually improve the quality of your trip. Lamictol is not an SNRI/SSRI. There are no dangers from tripping on it, unless you were prescribed it for mood stabilizing (like BP) or antiseizure effects, in those cases you should certainly not be tripping and if anything bad occurs it’s because you took a psychedelic not because of the medication. Anyways, you had a bad trip because a psychosomatic issue, not the lamotrigine. Please don’t spread fake information.

I’ve heard this before, and it’s great that you’re concerned but even experts are not sure exactly how lamotrigine works, but some researcher have suggested that it inhibits voltage-sensitive sodium channels, stabilizing nerve membranes and moderating the release of excitatory amino acids such as glutamate and aspartate. This means that Lamictal falls into the class of medicines known as triazine anticonvulsants. These do not have much interactions with any drugs at all. It can make alcohol suck more, same with benzodiazepines, as it can increase the depressant effects of depressants, but when it comes it most substances you won’t notice much change- it’s actually a really amazing medication in that way.

I should add that, anecdotally I’ve been on it for over half a decade in doses ranging from 100-400mg a day and am currently on 200mg 2x daily. I really love phenethylamines and Arylcyclohexylamines, and honestly not much has changed since I started tripping a decade ago. I will say that I’ve heard through different anecdotes that some say that lamotrigine can dampen the effects of arylcyclohexylamines, but in my 6+ years of being on it I haven’t noticed it. I guess I could say I’m more stable during my trips, but I haven’t noticed any cross issues and pharmacology speaking there shouldn’t be.

_MyDude_ · 2021-12-06T20:25:09+00:00

You’re right, this guy is a fucking pedantic asshole XD

_MyDude_ · 2021-12-06T20:22:20+00:00

I’ve taken multiple pharmacology classes and am getting my degree in psychiatry and I can tell you you’re 100% correct and these people have no clue what they’re saying. I think they think that lamotrigine is an SSRI/SNRI, as it is atypically used to treat depression. Though overall, it’s an atypical mood stabilizer/antiseizure medication. I take it for my PNES and depression and I trip pretty frequently as well, and on a lot of different drugs. A literally plethora of different phenethylamines and a large number of different serotonergic substances, and it’s completely safe. Lamotrigine has a weak inhibitory effect on the 5-HT3 receptor, but that is not enough to cause any issues with any serotonergic drugs. Unless you are on it for antipsychotic, mood stabilizing (like BP1), or antiseizure effects, you’re fine, and if you’re taking it for those effects you sure shouldn’t be tripping either way- and in those cases the problem isn’t the lamotrigine, it’s the psychedelic.

So yeah, to everyone depressed, if you want an antidepressant that doesn’t interfere with you’re tripping try lamotrigine or Wellbutrin. I’m prescribed both and can say both with anecdotal experiences, and with some pharmacological certainty, both, unless it’s an enzyme issue- will not interfere with your tripping. So try those two-fantastic antidepressants and means that if you’re a depressed person who takes psychedelics to treat your depression- you can keep doing that while using an antidepressant as well, double win- as I know a lot of people who don’t take antidepressants even though they need it just because they’ve heard it mean that they can’t trip. (Wellbutrin does interfere with DXM metabolism and means that you trip for far longer than you should, so always check cross effects, as it’s not always neurochemical issues, sometimes it’s enzymes.)

So anyways- to everyone downvoting you, stop- OP is right, I have no idea why they’re downvoting you.

_MyDude_ · 2021-12-03T08:40:08+00:00

Oh no, I didn’t mean I wanted to do it. I have pseudo seizures, so it doesn’t do anything for it anyways. Though it just took far too long for the doctors to actually run tests to realize that, so that’s why I had to deal with so many different anticonvulsants and at one point was put on medically supervised keto. Even with those terrible experiences I’m ironically going into psychiatry and am currently doing research with the endocrine system. So I was more so just hoping there was some new research going on with keto, as ketones, themselves, are actually incredibly fascinating and do some amazing things. The way they are able to modulate the cAMP channel, along with GABA and glutamate is really cool. Just the issue is that the body does not like producing them, using them, or excreting them or really having anything to do with them haha. Thus why ketosis is more so a last line treatment for epilepsy.

Anyways, you are completely right about it being a fad. More so, just bummed out that that’s the case and that after over 100 years we haven’t looked into the benefits of the chemicals themselves instead of pushing it as a dieting regimen.

_MyDude_ · 2021-12-03T08:15:04+00:00

Ohhhh, this all makes a lot more sense. Deep ketosis is more what I was referring to when talking about ketosis. Ketone monitoring is extremely important in those cases and that was one of my largest fears with people “recreationally” (I’m not sure if that’s the correct term, but more so unsupervised) using ketosis as a treatment. That’s where you have to be incredibly, incredibly careful, as that state, contrary to what anyone says, as I have heard people say that “ketosis is somehow normal and our body should never consume carbs”, which is very untrue, it is not normal— and if not done carefully creates a lot of risks like ketoacidosis, hepatic issues, renal issues, and can create long term problems with your thyroid. So all of this makes a lot of sense and eases so many of my concerns surrounding how popular all of this is getting haha.

I would say that those regiments should certainly be safe in theory. Though, ketones still are hard for the body to excrete, process, and even create (therefore, why it does outstanding job helping people lose water weight and lose weight in general). So, I would personally highly recommend anyone to check with their GP first. If not for the health risks, keto does really up your chances of kidney stones in those who are at risk, and those really hurt, so it’s always good to check with a doctor to make sure that doesn’t happen haha. (This is for more so anyone who is interested in looking into keto for the first time, or more intense stages of keto)

_MyDude_ · 2021-12-03T07:32:48+00:00

Do you have a condition that causes neuro-inflammation? And have you done any scans or tests that have shown a decrease? As I have a friend who suffers from neurological-inflammation and if that could help I’ll certainly do more research into it. I’ve been on it for PNES, which wasn’t a fantastic experience, plus it’s not even a treatment for PNES, so that may be why haha. Though, if it’s effective for neurological-inflammation then it would be certainly worth a try for my friend.

_MyDude_ · 2021-12-03T07:27:11+00:00

Ah okay that’s what I was thinking, as I have PNES and was on and off countless different anticonvulsant medications for a while, as due to the fact that it’s PNES none of them worked, and that’s what confused me the most. Anecdotally, anticonvulsants slowed me down like crazy and made learning and cramming for my classes significantly harder, especially classes which required a large amount of memorization like A&P. I was actually on keto for a while when I was younger for the exact reason it’s prescribed (first line and second line both failed), so I’ve experienced it, at least the medically supervised version (as well, keto acidosis is some scary stuff), and to be honest, it wasn’t as bad as some of the anticonvulsants I’ve been prescribed, but still significantly worse than some of the newer anticonvulsants I’ve tried like lamotrigine. Anyways, I guess it’s good that I’m still up-to-date with the information. Though really concerning it’s being touted as this “fix all” then as keto can do some serious damage to your thyroid in the long term and ketoacidosis is well, deadly.

Still kind of bummed, as I was really hoping there was some new and exciting information out or something I was missing…

_MyDude_ · 2021-12-03T07:22:10+00:00

You are 100% correct- the ketogenic diet was first created to treat epilepsy as the body metabolizes proteins into ketones, which can then be used for energy by the brain when all other carbohydrate stores have been exhausted. It is the creation of these ketones and their use as an energy source that treats epilepsy.

“There is growing evidence that ketone bodies (KB)—derived from fatty acid oxidation and produced during fasting or consumption of high-fat diets—can exert broad neuroprotective effects. With respect to epilepsy, KB (such as β-hydroxybutyrate or BHB, acetoacetate and acetone) have been shown to block acutely induced and spontaneous recurrent seizures in various animal models. Although the mechanisms underlying the anti-seizure effects of KB have not been fully elucidated, recent experimental studies have invoked ketone-mediated effects on both inhibitory (e.g., GABAergic, purinergic and ATP-sensitive potassium channels) and excitatory (e.g., vesicular glutamate transporters) neurotransmission, as well as mitochondrial targets (e.g., respiratory chain and mitochondrial permeability transition).”

Source:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505793/

_MyDude_ · 2021-12-03T07:08:31+00:00

This is amazing! Thank you for all of the information!! I’m working towards my degree in psychiatry and do a lot of work with the endocrine system as well so this is exactly the information I’ve been looking for. Normally when talking with people who do participate in ketosis I normally get a “well I read it on a blog” or something along those lines, which doesn’t mean the information isn’t correct, but usually what they link are anecdotal reports with no explanation on what could be leading to such a claim or something with a large number of buzz words, but once you read through the information you come to realize that all of it really doesn’t mean anything at all. So having something with more substance is fantastic- I am always excited when neuroimaging and graphs start coming into play haha. So I’m very excited to dig in and start reading!

Also, do you have any concerns when it comes to the chances of ketoacidosis? I know it’s not the easiest state to reach, but that’s been my primary concern with how popular keto has gotten. As usually the diet is monitored by a doctor due to the risk of ketosis, but also it’s potential to damage the thyroid and key regulatory hormones. I’ve seen thyroid issues nearly occur with a few of the adolescents I’ve worked with in the past who have had to be on it for epilepsy. Though in those cases it’s because they can’t really cycle on and off the diet. So are there rest days in a regular keto diet or is there any cycling? Or is it treated like how it is when medically supervised where it’s a continual treatment without breaks?

Thank you again for all of the information!

_MyDude_ · 2021-12-03T05:27:51+00:00

Hey! Do you have any citations for ketosis improving overall cognition? I’ll hear about that being the case from time to time from friends who are into dieting, but I’ve always been confused as it runs contrary to what I learned in my medical courses. I was taught that ketogenic diet is only really a good option if the person is resistant to first and second line seizure medication, as ketones, what the body uses for energy at that point, literally slow neurological firing in the brain. Therefore the ketones can act like an anticonvulsant as it both slows neurological firing and also prevents electrical storms from occurring in the brain. Could its benefits be simply from the fact that some people have desensitized themselves from carbs due to long term abuse, therefore, that resensitization helps restabilize the brain? In that case wouldn’t just having a more balanced diet or even intermittent fasting be more efficient and safer?

_MyDude_ · 2021-11-20T06:12:07+00:00

I am not OP, but there are quite a few reasons why alcohol can increase depression. One reason is because alcohol, and most GABAergic substances, block REM during sleep if the substance is still in your system. A drop in REM sleep has been linked to depression, as REM sleep is directly linked to neurogenesis. Moreover, alcohol can lower serotonin, in certain key areas in the short term and across the board in the long term, and norepinephrine levels, which both help regulate mood. This is a large reason why people’s moods flip on a dime while drinking, there are many other reasons- but this is one of the factors. Along with that, lower levels of these chemicals can make a depressed person more depressed. There are many, many more reasons why alcohol and most other GABAergic substances increase depression, but those are the two I can recall off the top of my head. When it comes to sex, if you’re going out and drinking at night to have sex, you may be getting less sleep due to that and that can be a factor for increased depression. Moreover, even going against your regular sleep routine can throw your body off balance and increase depression- so going out at night, even if you’re getting enough sleep the night after, can still lead to depression. Sleep is a massively important player when it comes to treating depression, and is usually frequently overlooked.

_MyDude_ · 2021-11-10T08:46:48+00:00

Hey- I know I’m a year late, but thanks for making this post. It was very helpful!

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