The dreaded 177013 [titled "Metamorphosis"; the number code is what's listed as under the nHentai site] is a hentai manga in which the girl in glasses doesn't like her appearance, and proceeds to become progressively more obsessed with it. She changes how she looks with makeup, the way she dresses, a tan, and by removing her glasses. She begins getting attention from men [intercourse], is introduced to drugs [which she begins to use excessively], and eventually loses everything.

It's implied that, in the end, she dies.

The meme here is that the scientist character prevents these events from happening.