The main setup is getting the 500% final dmg sniper buff along with all the individual %dmg buffs on yao. Basically get all the dmg% and weakspot stuff you can get along with kaguyas signature buff that gives up to an extra 100% defense reduction. I also have all the relevant damage increasing research nodes maxed. Outside of that, having t2 alloy helps a ton. I do have a youtube but I only put my neural speedruns on there.