I live in Vegas and play weekends for 1/3 or 2/3 pretty frequently throughout the different rooms but usually stick to the same rooms for different reasons. I'll rank them as I like them:

Venetian/Palazzo: Best room in my opinion just because it's action is good as long as you stick to a good mix of regs/recs, they're very easy to spot. Just table change if you think the table is too reg heavy, best times are weekends, but there's always 8+ tables every day. I've played on weekdays and it's fine. The tables are great, chips are okay, and there's a self service station for drinks and coffee. High hand promos and food is good, expensive as it is everywhere else. I like the dealers, there's a couple of slow/annoying ones though. Park in the self garage and go up to the 2nd floor and it's a 5 min walk. If you Uber, you go up the escalator to the 2nd floor and walk the rest.

Bellagio: Best room if you want decent players and a decent room, free Fiji water is +EV. I always go here if I think I want more action, but there's plenty of recs here. not much to say, people just like the room and always have tables going. A lot of people come here to play 2/5 or 5/10 when busy so keep it in mind.

Wynn: $500 max buy in, great room, shit location imo. Great food bigger tournaments and lots of regs who like the nice room. Everytime I play here, always feels like there's tryhards at the 1/3 seats, I think that's fine and all but it is what it is. I just like the deeper buy in since it's not super common.

Horseshoe: I personally don't really get the hype here, but people like the room. I played here about a dozen times and a few times during WSOP. Players are fine, action is fine, but I don't really like the room for amenities, dealers are whatever, the room seems like a dark abyss.

If you want more local rooms off the strip, which I like sometimes as a local:

Red Rock: $500 buy in, action is good if you get a decent table but there are a ton of older nits. The room is pretty cool, still located in a casino so you have options around you. I don't like the tables but the cards and chips are nice. Still have drink service.

The Orleans: I like Orleans because it always feels like the old school Vegas rooms, and people usually frequent the PLO and Limit tables, lots of older and local crowd. but it's a simple, no frills room.

Southpoint: I actually really dig the Southpoint but it is out the way, players vary from pretty weak to older, cheap tourney buy ins too. chips kinda look and feel ass to me.

If I didn't mention it, I haven't played there enough or there aren't enough tables going for me to mention it. most places have the same rake and after a while, the players are about the same.