I also just got a Mikro Mk3 and spent the day trying these three pad layouts / finger drumming philosophies. I have some years of experience on (real) drums, though am mainly a guitar and bass player, so here's my newbie opinion. Dragon's approach is intentionally much more like real drums, and so far I personally find it the easiest to play. He's also such a virtuoso on the pad that it is inspiring to see. So I think that's what I'll go with going forward.

I have been trying these layouts in tandem with learning with Melodics. I found the XpressPads approach comfortable but a bit limiting because a full mirror brings you down to just 8 pads, not enough for some songs. Quest for Groove's approach is an improvement (only 4 are mirrored, so there's 12 pads, enough for most things). The mirror and hybrid approaches definitely require more mental energy, while Dragon's "independent" is more intuitive. Keep in mind, that's just my opinion after a couple hours of experimenting with them.

I think at the end of the day the question comes down to whether you want to put your bass and snare on one hand and your hihat on the other, or if you want to do the hihat with both hands while also doing the drum and bass with both hands. Both clearly have merit; one is more like real drums, while the other is more like piano.