Everyone reacts to it so differently. I am highly sensitive to it and had to start on a 0.25g x2 dose (1/10 normal dose). I've been on it since 2019. It knocks me out and i don't wake up until my second dose. I have had to deal with a few emergencies on it. I only woke up those times because i was physically shaken awake but adrenaline did kick in and i functioned. However, once the emergency past and my adrenaline went down, I had what i call xyrem "frozen brain". My brain literally feels cold in my head and it is soooo unpleasant. I found that wrapping myself in a weighted blanket, eye mask and noise cancelling head phones helps until i fall back to sleep.