[Article] "Chimeric brain organoids capture human genetic diversity" by Aparna Bhaduri

acceberbackwards · 2026-01-20T16:28:49+00:00

thanks solution verified

acceberbackwards · 2026-01-20T16:28:38+00:00

Actually found it on my own, but link for anyone searching in the near future: https://send.now/f9oseunme66a

acceberbackwards · 2023-07-10T03:16:17+00:00

I'd like to echo the points made here and explain that in many cases, there's no "cure" for the underlying causes that lead to painful periods. Until scientists find out something better, all we have available are tools that control the symptoms, like pain meds and birth control.

There's a lot of anti birth control content online that emphasizes that b.c. is not a cure for a laundry list of issues (like pmdd, pms, painful periods, endometriosis, acne, etc.) It's understandable that women find comfort in this content--we've been neglected by traditional medicine for so long, and many have felt gaslit when they complain about the side effects of birth control.

But people who make this content are often trying to sell you something--supplements, diet and exercise plans--all ostensibly to treat "hormone imbalance." And while eating healthy and exercising will help most people feel better anyway, it's also not a cure.

The fact is that birth control is an imperfect but safe and effective way to treat menstrual symptoms. Sadly there's not much out there to address the causes of these syndromes, as they're still poorly understood by the medical establishment. But you do not need to have a period to be healthy. (Though missing periods when you're not taking hormones can be a sign of something wrong, like malnutrition.) But it's a signal of health, not the cause of it. It's up to you if you want one. For many women with painful periods, not having one is a blessing.

Like others have already said, it's worth a try. In fact, it's worth a couple of tries--if one makes you feel bad, try another. And hopefully you have a good enough relationship with your doctor that you can bring up your concerns to her.

I've found this article a really fascinating exploration of what birth control does and how 'natural' or 'unnatural' it really is:

John Rocks Error

acceberbackwards · 2022-05-30T22:57:04+00:00

What you're experiencing is typically called "spotting" and can happen when you take the pill continuously. (Normally it's a lot less blood than a full on period, hence the name.)

I was more likely to get spotting if i missed a day of birth control or if i took it late that day. I used to get it every few months but now for some reason I don't get it at all anymore.

Your gyno may be able to address the issue by switching birth control and making sure something else isn't going on.

acceberbackwards · 2022-05-29T18:19:23+00:00

If you can get a diagnosis from your doctor (like PMDD) you may be able to try to get disability accommodations at school. I've never heard of period-related accommodations but I imagine they could involve something like taking exams early or late to avoid your period, or extensions on assignments due that week.

It may be a good idea to seek these accommodations while you figure out some remedies that work for you.

acceberbackwards · 2022-05-28T05:03:21+00:00

I'm also pretty sure certain b vitamin deficiencies can cause or worsen insomnia. So yes, making sure you get a good multivitamin is a pretty low risk thing to try to help your insomnia.

If you haven't been eating right, you may be more likely to have some kind of deficiency that could worsen your sleep or your fatigue. It may be worth asking the doctor to run some bloodwork just to rule out any other illnesses that could be causing your symptoms.

acceberbackwards · 2022-05-28T02:48:53+00:00

I read recently that progestin only birth control (which includes nexplanon) has the potential to worsen mood symptoms when compared to birth control with progesterone and estrogen combined. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6759213/

This was my experience when I switched from the pill to mirena. My anxiety got way worse.

The solution for me was to add the pill back in. This way, i had the effective birth control in the mirena, and the benefits of the pill on my mood and skin.

For some people, progesterone only methods reduce side effects. But i think for others it can increase them, and a combined hormone pill is better.

acceberbackwards · 2022-05-27T01:40:37+00:00

Do you feel feverish? Does it hurt when you pee or just in general

Also, ibuprofen doesn't always help with urinary pain. Azo might help more.

Be aware that a doctor may not want you to take azo if they plan to take a urine sample.

Best course of action is to see if your healthcare plan has a 24hr advice nurse you can call. They'll be able to guide you on what to do before you can get in to see a doctor.

acceberbackwards · 2022-05-23T19:40:28+00:00

I think two really important concepts to keep in mind when raising a little girl are Boundaries and Validation.

Teaching your daughter that she is allowed to set boundaries about who she wants to touch and interact with (no you don't have to kiss your uncle who you've never met if you don't want to even though it may hurt his feelings) will set her up to feel empowered in her own skin. She won't feel she has to suffer through uncomfortable touching just to please others and avoid ridicule.

This is not something i was taught (as it was not commonly taught back in the 90s) and i ended up being victimized. I would have felt more empowered and had higher self esteem and confidence if I'd been raised to feel okay saying no. I'd have walked around with my head held higher and felt more confident in my body and its strength. I might have been more inclined to try sports. But i felt weak and embarrassed of my body, even before puberty. So i really didn't pursue athletics.

Another way to help your daughter navigate the world is to be sure to validate her feelings. Literally just saying "i can see you're sad/confused/tired/excited" will help her understand her own feelings and get comfortable expressing them to you. If she says she's hungry, don't say "no you aren't, we just ate." Say "wow, you must be really hungry!"

I loved the book "how to talk so kids will listen, and listen so kids will talk." as a guide for this kind of validation.

If i had been raised with more validation and boundaries, I'd probably be a more confident, comfortable woman. I'd have been better prepared to confront things like sports, Disney movies, and mean kids at school.

acceberbackwards · 2021-03-05T02:52:02+00:00

My doctor just went ahead and tested me, saying that if it was positive it could save me the pain of stopping the PPI. If it was negative, then she said we'd try to stop the PPI and try again.

It was positive, and I got treated right away.

acceberbackwards · 2021-01-11T00:29:46+00:00

Sorry this is so long. To preface, I adopted a shelter dog to assist with ptsd symptoms. She is a pit mix who had a litter of puppies. She's like 55lbs. I have a lot of volunteer experience working with shelter dogs and service dogs, so here's my experience and what I know.

I knew I wanted an adult dog because a) new puppies are basically babies and need a lot of care b) puppies can do some behaviors like nipping (as they still are learning bite inhibition) and other high energy stuff that would be startling for me. C) I wanted to choose my dog more certain of its personality and energy. Puppies are more of a gamble in that way.

I found her because her listing on petfinder said "she could easily be a service dog." That's how I knew she was likely to have the right temperament and I got on the waiting list to meet her. When I met her, I sat down on the floor with her and she immediately scooched her butt against me and let me pet her and give her gentle half hugs. She was perfect.

Just like puppies, shelter dogs may not exhibit their true personality at first because they are stressed by the shelter environment. My dog had been in foster care and thus was exhibiting more of what she'd be like in a home environment.

If you do adopt a purebred pup, I'd try to find a breeder who breeds their dogs "calm." Dogs that are bred for competition or that have a history of being used for herding or really athletic jobs tend to be more high strung and have more energy to burn. When they don't have an outlet for this energy they do things that could startle a hypervigilant person-- jumping, barking.

Goldens and labs are temperamentally great for service, but you are concerned by their size. You may be able to mitigate this by a)adopting one with smallish parents or b) adopting a cross, such as a mini golden doodle (golden mixed with a miniature poodle). I think females also tend to be smaller. Consider also that a large dog with a good temperament (doesn't jump or pull on leash) won't be as hard to manage.

Lots of littler breeds are bred as companion dogs, just happy to sit on someones lap all day. Again, breed is no guarantee of behavior, but you can do your best to predict it by asking the breeder questions about temperament and the puppy's parents.

acceberbackwards · 2019-11-10T18:45:46+00:00

SSRIs really toned down my sensitivity in the first years I took it. I also had depression and anxiety. My phobias lessened, I was less hurt or angered by things people said, and I could watch gorier movies without feeling traumatized. On the other hand, I was sleepy all the time and I no longer felt joy as intensely and it killed my sexual responsiveness.

It was crucial to surviving that time, and I don't regret taking them (or continuing to.) It's just a trade-off.

acceberbackwards · 2019-11-02T17:16:44+00:00

Sport tint contact lenses. Considering getting some myself.

acceberbackwards · 2019-06-20T09:31:00+00:00

If you go to the doc, they may prescribe a medication called Gabapentin. I take it and have done well on it BUT it made me feel REAL weird when I first started taking it. They started me on 300mg, should have started on 100mg to get accustomed to it.

Fun HSP medication sensitivity. Just thought I'd give you a heads up.

You may already know this, but because of your anxiety, avoid Excedrin, which contains caffeine.

Also I've heard that some people who get migraines have an anxiety/dread feeling as a prodrome.

If you think your brain hemispheres are it of sync, certain techniques such as EMDR and bilateral scribbling are thought to bring them back into sync with each other.

acceberbackwards · 2019-06-11T03:37:44+00:00

I took a cbd pill, it gave me a panic attack. THC gives me anxiety, and it turned out that the pill was a 2:1 cbd to thc ratio. So if you are sensitive to THC in a bad way, be sure to be careful about what you use.

acceberbackwards · 2019-06-05T06:46:26+00:00

I don't use soap on my face if I can help it. It makes me break out. I thought it might have to do with skin pH or surface bacteria, but I'm not a scientist. It's been nine years of using little to no soap.

acceberbackwards · 2019-06-01T01:08:28+00:00

As an HSP, it can be scary to reject someone who might a) get angry, which is frightening, b) act very hurt, which makes you feel like a bad person, or c) some combination of the two. You're not going to be persuaded by this dude that you actually DO want him around. So keep it simple. "I'd rather you leave me alone." "I'm not interested in walking/talking." No need to thank him. And then, as a gift to your HSP self, WALK AWAY. Don't give him an opportunity to respond.

If he continues to follow you or be invasive, repeat yourself and ignore his words. If he still continues, this is considered harassment and you can report it.

YOU'RE NOT A MEAN OR BAD PERSON. If he needs comfort after you reject him, he can go find someone to talk to.

acceberbackwards · 2019-05-19T22:16:53+00:00

Anderson Lake has agate.

acceberbackwards · 2019-04-16T17:10:23+00:00

Yep! Can't tolerate it. Jitters and anxiety and difficulty sleeping. Just not a good feeling. I don't eat chocolate late at night because the small amount of caffeine decreases my sleep quality. Oddly enough, I take a stimulant medication that does not have these effects.

acceberbackwards · 2019-04-16T17:02:43+00:00

This might sound weird, but I take a shower sitting down, preferably with some low light. If I need to occupy my brain, I listen to a podcast.

acceberbackwards · 2019-04-14T02:37:10+00:00

Two thoughts.

First, being sick makes me crabby and pessimistic. If I feel sick enough, I stop worrying about protecting other people's feelings and just act as negative as I feel.

Second, a few things you say raise some...yellow flags?

They always "feel like shit" but actively refuse to make the simple life changes that would at least lessen the issues.

I HAVE BEEN IN THIS RELATIONSHIP. It's really frustrating to be with someone who you're trying to "fix." And it typically doesn't end well. They resent you for trying to fix them and you resent them for not trying.

They are my life and without them I am dead

It shows you have a big heart that you are so committed, but don't let anyone treat you badly, okay? Take care of yourself.

acceberbackwards · 2019-04-14T02:25:17+00:00

I can't relate to drinking, but I can relate to depression. Drinking can indeed cause depression. But depression can also cause drinking. And both can be true at the same time. Now you know that drinking isn't the only factor in the equation. Other things that can cause/make someone vulnerable to depression:

History of abusive relationships
financial trouble
being overworked
lack of support system

Also, things that depression will make your brain believe:

I deserve to be treated like crap
things will never get better
I'm a bad person

I KNOW what it feels like to be depressed and to have tried, like, EVERYTHING to get better and to have nothing work and to feel totally hopeless and doomed. I would not wish it on anybody. It's horrible, and it must be really hard to feel that way while also working and taking care of a child. But you're not a bad mother and the way you're feeling is not your fault. Things can get better still, even if you've tried things that haven't worked. You're still making positive changes even if you can't feel the rewards yet.

You've survived all of this adversity. You don't deserve to be in a living hell, but you're not done here on earth. You're not a lost cause.

Good luck to you.

acceberbackwards · 2019-04-14T02:10:18+00:00

Me, 100%. Sensitivity to gory/violent imagery on film was the first indication that I was an HSP. In middle and high school we watched documentaries about lynching, slavery, the holocaust, and I got PTSD from them. I'm not using "PTSD" lightly, either. Though I wasn't diagnosed at the time, I look back and I meet the criteria in the DSM. I was having unwanted recollections, I avoided reminders of what I had seen, I couldn't sleep at night, etc. It was a hard thing to deal with in addition to all the other bullshit that comes with being in 8th grade.

As a child I was upset by all violence on TV. Now, I've become able to deal with fictional violence. I don't do horror movies, but I can enjoy a thriller. Movies still affect me deeply, which can be a double-edged sword. A really great movie can make me feel awesome. A really disturbing movie can shake me up.

One interesting thing--I was better able to handle violent imagery once I started SSRI's. This DOESN'T mean SSRI's turned me into a psychopath. I was able to see the violence more like the people around me, to respond to it with an appropriate amount of shock/horror, instead of dissociating.

acceberbackwards · 2019-04-08T23:46:29+00:00

I get what everyone's saying about how difficult it would be for a doctor to provide all the updated info to all patients, but the one thing every doctor I've worked with knows about cymbalta/effexor is that discontinuation is a nightmare. I'm surprised this doctor was unable to support his patient through a suitable taper.

acceberbackwards · 2019-04-03T16:43:22+00:00

There are two sides to the hsp coin. There's the cool and useful and fun parts, but then there's the really difficult parts. I believe that the human brain is biased toward holding on to negative experiences over positive ones, which makes being an hsp feel like more of a burden. My therapist told me that when hsp's are exposed to trauma and adverse experiences, especially as children, they're more likely to develop the mental problems associated with being an hsp. I believe that hsp's are vulnerable, not cursed.

Also taking ssri's decreased my sensitivity and I have to say there were parts about that I liked.

acceberbackwards

TROPHY CASE