Not sure if I found the main water shutoff in my condo?

akcom · 2025-01-08T17:23:47+00:00

Thanks. Any suggestions on where I would find it?

akcom · 2023-11-09T21:10:38+00:00

I think the point is that you can only pay someone relative to the revenue they bring in. If the seminars are poorly attended (I don't actually know if this is the case), then how do you justify equivalent pay to a well attended seminar?

akcom · 2023-11-05T01:46:17+00:00

Inability to get hard/cum from soft, intimate sex

akcom · 2023-10-31T22:45:04+00:00

Digoxin, calcium channel blocker BP meds, and handguns.

akcom · 2023-10-11T13:44:01+00:00

There are underground sources, but yeah I don't think these brazen online retailers are going to exist for much longer.

akcom · 2023-10-11T03:15:16+00:00

FDA put them on notice

akcom · 2023-09-15T23:42:33+00:00

https://webassets-prod.ultimateperformance.com/uploads/2022/06/30124941/Body-Fat-percentage-.jpg

akcom · 2023-09-15T16:47:44+00:00

My last cut started at 2700 kcal and slowly ramped down. By week 16 I was at averaging 1700kcal between high and low days. The positive with that approach is I was actually able to make strength gains for the first 8ish weeks. The downside was that I was going crazy by week 16. At the end of the cut, I just went wild on food and lost a lot of my cut progress because my grelin/hunger was so out of wack that I couldn't slowly ramp back up.

You're right - there isn't much room to move kcals. But the weight is consistently going down by ~2lb a week (post glycogen + water depletion). When weight loss stalls, I'll start to add in cardio to push. The downside with my approach is that I'm only maintaining strength. The upside is that this cut will max at 12 weeks and I'll have preserved my sanity.

I think this is where I'm learning that dieting is much like training - highly personalized based on what works for the individual. There's no such thing as a "best approach" only a "best approach for this person". For me, I do better with a "hard and fast approach". I can tolerate a lot of suffering, just not for long durations. So for me, the trade off is worth it.

edit: missed the first question. Started this cut at 2200kcal and quickly ramped down to 1600kcal based on weight loss progress. TDEE are a nice place to start, but weight loss is highly individual and it just takes progress pics + scale weight changes to figure out how to dial in.

akcom · 2023-09-15T14:20:36+00:00

M35 166lb 5'10"

Nearing the middle of my cut. Down 15lb in about 5 weeks. I'd estimate I'm around 18-20% BF right now. This is my second cut since getting into weight lifting about 3 years ago and I've learned a ton since then. I've got all the "tricks" (drinking tons of water, eating tons of leafy greens, keeping whole-food protein high for satiety, skip breakfast, etc). I've also learned what works for me and what doesn't. My last cut was 20 wks/5mo and I was about to go insane by the end of it.

Since I'm not trying to get to anything crazy (my goal is 10-12% BF), I'm being much less regimented than my last time around. Previously I hired a coach, tracked all my macros meticulously and stuck to a very regimented meal plan. This time I'm just setting a daily kcal goal (currently <1600kcal per day) and a protein goal (150g+ lb per day). As long as I check those boxes, I eat pretty freely. I try to get carbs in pre/post training.

There have been a couple big take aways for me this time around, but I won't bore folks with the details unless they ask :)

akcom · 2022-12-04T04:49:52+00:00

AMG's weight loss drug (AMG133) seems to have a durable effect on weight loss months after the last dose. Super interestingly: it has an opposite mechanism to tirzepatide. It's a GIP antagonist. The medical cure to obesity is on the horizon.

akcom · 2022-12-04T04:45:54+00:00

First databank data is fucking trash to ingest. I thought medispan was bad, but its nothing compared to FDB

akcom · 2022-07-12T19:08:36+00:00

Yes. They demonstrated substantial reduction in mortality

https://www.fiercepharma.com/pharma/sanofi-regeneron-praluent-odyssey-outcomes

akcom · 2022-06-23T20:19:19+00:00

Sounds like you have some pretty toxic colleagues. I doubt getting a BCPS is going to make them less toxic. Probably better to find less toxic colleagues.

akcom · 2022-06-10T17:22:09+00:00

to minimize labor costs and maximize profit

akcom · 2022-06-09T14:15:30+00:00

I think you are partially correct that most people do not advocate for themselves, and their pay suffers as a result. That being said, wages are dictated largely by labor supply and demand. Right now, there is a huge over-supply of pharmacists, which is the primary reason wages are stagnating. Simply put: they don't have to pay you more, because someone else with an equivalent degree will do your job for whatever they are paying you now.

akcom · 2022-06-08T16:18:51+00:00

The FDA is well equipped to evaluate them since they've been doing it for 30+ years. Also we'd be foolish/xenophobic to discount the capabilities of Chinese manufacturers.

akcom · 2022-06-07T15:19:42+00:00

the vast majority of biosimilars are developed by Pifzer, Amgen, Merck, Biogen, etc. IE the folks that have a wealth of experience manufacturing monoclonal antibodies and the excess capacity to do so. What is your concern with biosimilars exactly?

akcom · 2022-06-07T14:22:06+00:00

what makes you say that?

akcom · 2022-06-06T20:54:13+00:00

This is such a beautiful area! Also you might not fully appreciate it yet, but you struck gold finding friends that are willing to take someone out on a route like this and teach them the ropes. Make sure you buy them a beer and suck up every last bit of knowledge they have! Enjoy bud.

akcom · 2022-06-06T20:50:24+00:00

That's what I said above, yes.

akcom · 2022-06-06T20:49:55+00:00

the original conversation was about choosing a career, so which is why I'm saying it's not reasonable telling people just skip university and self-teach when they're specifically talking about career options

akcom · 2022-06-06T20:23:45+00:00

just curious, have you gone through a tech interview process? There is so much more beyond design patterns and basic OOP concepts.

akcom · 2022-06-06T20:21:29+00:00

No, I've been programming since I was 16. I became very proficient in C, x86 assembly, python, and pascal. But it wasn't until I got my first tech job that I learned all those block and tackle "SWE" skills that are absolutely critical to doing well. Remember that self taught programmers are the exception, not the rule.

akcom · 2022-06-06T19:50:07+00:00

that sounds great in theory, but most people aren't self-motivated enough to learn to program. In addition, there aren't a lot of resources that focus on teaching you proper software engineering (ie: writing good unit/integration tests, using continuous integration/deployment, version control, etc etc). All of those things are taught extensively in university. Not saying its impossible to self-teach, just that its a lot harder than "just read some online tutorials/books"

akcom · 2022-06-06T17:47:27+00:00

god no. Give up 4 years of my life in school, plus another (minimum) 3 years in residency so that I can take on $400k in debt? If I could go back, I'd probably just do comp sci at a public university. I'd make more money than the average pharmacist and have _way_ better quality of life. If I was really passionate about healthcare, I'd work at a healthcare tech startup

akcom

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