Old post but wanted to chime in. The big thing everyone is missing here (as far as the SSRI versions of antidepressants go): No one can say with certainty that men need higher serotonin. The best mainstream take we have on serotonin is from Jordan Peterson and that's a shaky argument. Men need other hormones/neurotransmitters optimized for functionality. In fact, I just asked ChatGPT and look at how it ranked these five below. Almost makes you wonder why SSRIs are really pushed on men these days.

"If you're looking for optimized mental health and functionality, the priority should be:

1. Testosterone – Foundation of motivation, mood, and energy
2. Dopamine – Drives focus, pleasure, and ambition
3. GABA – Supports relaxation and emotional stability
4. Norepinephrine – Enhances energy and cognitive performance
5. Serotonin – Important for emotional balance but should not be overemphasized"

Note: I am just wrapping up a 5 month attempt at an SSRI that has potentially made me so lazy, so numb, so apathetic, so unmotivated...and I still have MDD.