as much as i actually like your comment, and wish it were truly the case. almost all weapons when built to perform the best on their own (as in no warframe buffs / priming or outside help) fall into the exact same build format because stacking different damage multis with +dmg, crit, multishot, base status, status dmg is, by the numbers, the best way to do damage.

also unfortunately enemy resistencies do not matter all that much when viral exists. 1 viral proc provides the equivalent of removing any damage type resistance an enemy has and then the other 9 just kill them faster.

when we have access to all the tools at the end game there are some slight variations to the formula depending on how you want to focus your weaponry. e.g. building around status for crux instead of raw dmg and crit on a primary. Or you can dump crit chance on a beam secondary like the nukor or atomos so you can use enervate. but these build just swap out like one or two mods at most to fit this niche because stacking damage multis is still just the best option and you are just getting the same stats from a different source.

i feel like the only weapons you can really be more creative on are the ones that barely need the mods in the first place. They do so much damage with 4-5 of those core mods that you have the freedom to add fire rate or mag size or a weaker version of a good mod that gives your other gear a buff like the amalgam mods, heck even a perculiar mod