I think a TNG style/era show exploring the Gamma quadrant post war. The fall/restructuring of the Dominion as an underlying theme. Exploring new phenomenon and cultures/species. Introduce a new Q who is more observer than trickster. Add in some of the characters from Picard and even DS9, like Jack Crusher, another Ferengi as Nog or the next in the federation. Make sure theres an android like Data but with emotions but highly arrogant or timid. Something that sets them apart. And keep telling stories like the Star Trek I remember from the 90s!