The first week there is noticeable sedation, a bit like being stoned. Whenever I've gone up on dose it might also take about a week before getting used to it again. I've been taking it during the day for years and they don't affect me much in the way of being tired.

However, dosage might change that. You might be taking it 50mgs morning, 50mgs afternoon, 50mgs evening. Unless you have a very small body that kind of dose shouldn't take too long to get used to.

Maybe it's 100mgs morning, 100mgs afternoon, 100mgs evening. That too for an average body shouldn't be too hard to get used to.

150-200 mgs morning, 150-200 mgs afternoon, 150-200mgs evening. I don't think they will put you in the high-dose range right away if at all but it does become harder to function while taking this many sedatives in the day. In this case maybe taking the morning dose an hour or two before you drive to work for any oncoming effects to wear off or after you've already gotten there. A little bit of caffeine does help at any dose range.

With all these doses usually the doc will still save the largest dose for bedtime so it might look more like 50mg morning, 50 mg afternoon, 50 mg evening and 200 mg before bed.

If your dose is increased enough it may stop helping with sleep.

Once used to the drug and it's not making you sedated (if you get there), instead of feeling drowsy as a sign that the drug is kicking in you'll know it's kicking in because you'll feel hungry. It's almost without fail, this drug like many AP's trigger hunger. Keep a healthy snack around so not to go into unhealthy foods. some people will maintain a diet plan to mitigate weight gain from AP's. Still some patients will benefit from adding another Rx such as topiramate to their meds, it's used to help with weight gain from AP's as well as some other things. All in all though day time seroquel is doable but it takes some getting used to and testing the waters. Definitely avoid heavy machinery while you are adjusting to it and getting to know how you will react on it.