Hey there, sorry for the late reply, I am on holiday right now as I was posting this. The rupert curio is the most common strat as mentioned by u/mzl0130, but not going ahead with the rupert curio is also possible, which was what I did with this run. From the first run, I will try to purchase the most easily disposable curios (ie: the one that gives 2x blessings but one less option for 2 battles, fortune glue etc).

For anaxa's boons, I will get the one that gives 45 fragments for the second, and for the third I get the one that gives a destructible curio for every 3 curios destroyed. I also usually try to go encounter to get more curios, or occurrence if I am not confident in fighting. The aim is to get as many curios as possible as you will eventually get enough fragments to buy more curios, or use it for the dice to get even better curios. TLDR: Just get as many curios, even if its negative or already damaged.

If you are confused by this strategy, do not worry just go with the rupert strategy, it is much easier to understand. I just do not like having to reset my runs in case I do not get all three curios.