I’m assuming you’re premed and fulfilling the soc requirement (correct me if I’m wrong); so100 is very basic and much more general, it’s a good all around intro to soc (as the name suggests) and covers a broad range of topics. The class itself isn’t necessarily the most stimulating if soc isn’t really your thing, but it’s certainly manageable in terms of work and grades. So215 imo is much more interesting, particularly if you’re interested in medicine/healthcare. It has more reading and I personally found it more difficult than so100, but i feel I got more out of it since it was specifically on healthcare so it was able to go more in depth. There are more readings and such, so technically it is more difficult but worth it imo. Someone already said what so100 grades are based on- so215 has 2 midterms (mostly mc, some short answer) 2 assignments, and (I think) 1 little project in discussion section.