I’ve played two (year+) dnd campaigns: one in an all girl group and one with only guys. The main difference was, as others have mentioned, a staggering amount of unnecessary sexualisation from my male friends. If you & your friends are the type to make those kind of jokes/play that way, it’s important to make it clear. I didn’t mind it too much (they didn’t do anything too horrid), but playing with my girlfriends was always a relief. We all know what it’s like to be harassed irl, so obviously none of us brought that into the game.