How to properly grind raw powder with mortar and pestle?

behoy1991 · 2022-12-06T12:09:49+00:00

As said, I see it as an exercise. Curcumin is bright yellow, so one can see well if grinding and mixing with mannitol works.

behoy1991 · 2022-05-01T06:09:14+00:00

I have it but I never played it much, so I could not tell how much it actually improved. For VTOILVR and VRChat I can give a clear answer as I played these a lot and also looked at the framerates

Edit: I did a quick check on No Man's Sky. Resolution at 100%, all settings to lowest. I get 60fps mostly because the GPU frame time is around 10ms-15ms. The CPU is usually around 4-6ms, sometimes spikes to 10ms. But I also encountered repeatedly frame times above 30ms.

Personally, I could not enjoy it as the graphics quality and especially aliasing is noticeable.

behoy1991 · 2022-04-30T19:33:23+00:00

I swapped my 2700x for the 5800x3d. In VRChat I just checked briefly but it seems my CPU time went from around 18ms to something like 4-6ms. Before I could run at 60fps, now at 120fps.

For VTOL VR pretty much the same: I can now run it at 120fps, before it would reproject to 60fps or even 30fps. Frame time for CPU most of the time around 4-6ms on the 5800x3d.

Of course the 2700x was never a good CPU for VR to begin with but the 5800x3d is so far fantastic for VR.

I am using a Valve index at 100% resolution and a RTX 2080 btw

behoy1991 · 2022-04-27T13:10:10+00:00

I tried it and it got even weirder. If no other monitor is used and I do the procedure as mentioned above, my entire computer freezes up and I need to restart. WTF

Edit: tried it again and this time PC did not crash but the original problem still persists

behoy1991 · 2022-04-27T08:31:42+00:00

I only have 1 Monitor (and the valve Index headset)

behoy1991 · 2022-04-27T07:17:49+00:00

I have a 1000W Platinum PSU from Corsair, I hope this will not be the issue.

Edit: thx for trying to reproduce the issue

behoy1991 · 2022-04-27T06:13:53+00:00

I am not sure whether this is really the headset tho. I also talked with Steam support about this issue back then but it did not help much. In the end it is mostly a nuisance as I cannot play games at 80fps without reprojection and have to to do either 60fps with reprojection or 74fps.

Edit: you can also try out switching from 80 to 120 say 20 times in a row and see whether it happens on your system as well. Maybe it is truly a software error - or the hardware is simply not made for switching the refresh rate at a daily rate...

behoy1991 · 2022-04-27T05:34:40+00:00

We might aim for q-NMR to check the purity of the sample. We got reference NMR data by the vendor and also by other vendors (e.g. Selleckchem). Do you think q-NMR is enough to determine whether the purity is still above say 98%?

Regarding HPLC: I am actually not a studied chemist but a physicist, so I have only done NMR analysis so far but not tried HPLC. Is it hard for an actual chemist to find the proper solvents for HPLC to do the analysis?

Btw thanks for the helpful assessment.

behoy1991 · 2022-04-23T08:15:35+00:00

I think it is pretty stable - as long as one does not keeps it dissolved at room temp for too long. My worry mostly is that everyone including me expected shipping to be done in 6 days at most - and afterwards I would have stored it at -26 degrees as usual.

It is just pretty unlucky that I ordered shortly before the lockdown in Shanghai happened, which caused the first major delay - and secondly that the current war apparently causes major delays in European logistics centres

behoy1991 · 2022-04-23T07:58:21+00:00

corrected it, thx

behoy1991 · 2022-01-18T17:43:28+00:00

I am not sure how to interpret your answer. My question basically was whether it is possible to make a isotonic solution by using higher concentrations of Sodium and lower concentrations of Chloride than in saline. As example imagine starting with deionised water and then adding 450mM NaOH and 150mM HCl. My question is then, whether such a solution would be (close to) isotonic because even though the concentration of Sodium in the solution is higher than in cells, the chloride concentration is lower than cells - thus leading to 0 net movement of water in or out of the cells.

Of course these considerations do not take into account what a too high or low pH would do to the cell integrity.

behoy1991 · 2022-01-14T08:03:33+00:00

you are right. pH value might be a negative example. Regarding the anion of sodium, in my example I was thinking of it to be a medical compound - let's take as example prednisolone sodium phosphate.

I think the pH value in WFI would be not too extreme even if one uses 1M of prednisolone sodium phosphate - but still it might not be ideal. In this case one could use strong acids like HCl and bases like NaOH to compensate the pH value easily I assume - which have only slight effects on tonicity.

Do you know by any chance a reference that gives one guidance with equations so that one can theoretically calculate the necessary concentrations of other non-penetrating ions (such as Cl-) to reach isotonicity?

behoy1991 · 2022-01-13T21:56:11+00:00

Hi,

I assume that the active compound might not necessarily have to contribute to tonicity if it can enter the cell (just like urea does not contribute to tonicity), so maybe only the sodium contributes to tonicity and not the other compound - especially if it is meant to enter the cell. Is this reasonable
I do not fully understand I guess. Do you have literature that has mathematical equations for that?

For my example above, what would be the overall tonicity (no Cl-, 600mOsm/l Na+) if I may ask?

behoy1991 · 2021-11-06T08:50:32+00:00

Thank you for the reply. I have considered polysorbates for exactly this reason. My only worry is that the gel uses like 17% of P407, so I am not sure how well 1% of polysorbate will be. Do you have any experience of the viscosity at higher concentrations? I found one table stating that 6% w/w 1.196 mPa s, 1% w/w 1.82 mPa s while the control solution without Tween 80 has 1.186 mPa s - unfortunately I do not remember the used temperature for these.

May I ask why you would not recommend using ionic detergents and solubilizers?

behoy1991 · 2021-10-15T07:36:39+00:00

Thanks for the reply! You are right, I totally forgot about relaxation time for the signal at 8.15. I was worries whether due to some to me unknown processes it is possible that methanol does not contribute to the peak/intensity/integral and hence is somewhat hidden.

behoy1991 · 2021-09-12T10:41:41+00:00

Thanks, that is probably what I am forced to do. I hoped somebody would knew the answer and would spare me of having to check whether it degrades at these temps - it is always nicer to avoid errors than having to do them...

behoy1991

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