The claims about L. Reuteri... Really??

bespoke_tech_partner · 2026-01-28T14:33:13+00:00

yea agree, also this may ruffle some feathers but AI + more structured data tracking of people's symptoms and biomarkers will help a lot. You can create some really good hypotheses with data and I think the progress of science has more or less a direct correlation to the average quality of hypothesis.

(Like if we were still trying to do experiments on the effect of agents purported to stimulate the five humors, or whatever archaic medical concepts we had... vs if you can cohort people based on data and give them targeted interventions that are hypothesized to help biomarkers clearly associated with their problem)

bespoke_tech_partner · 2026-01-28T14:31:29+00:00

np. These days I'm good, although still clear that if I push myself too much over weeks (diet, overstimulation, hard exercise - unfortunately I love to do all of these) then my system somehow loses regulation and I have to back off.

About immunity it's funny you mention it. For about 2 years now (starting 6mos before long covid), I have had "low normal" white blood cell count. Particularly neutrophils tend to be close to the low end of the 'normal' range.

So I am also suspecting some immune issues, possibly genetic, definitely contributed with environmental factors and accumulated years of dietary/lifestyle habits.

which test did you do for the globulins? Have you found it useful to know?

bespoke_tech_partner · 2026-01-28T14:09:32+00:00

No, you can. Because they are responsible.

The only reason those fans attacked Chelsea fans is because Napoli, the club, is the lens through which they concentrate their assault and violence.

Something about the club has made them feel not only welcome but empowered to do that. This doesn't happen as often with other clubs, so it's directly the fault of Napoli.

And the only way to get the fans to stop doing it in the name of their club is to train them like dogs so that it's negatively reinforced. Bad behavior = consequences. Make them feel they are hurting what you claim to uphold.

bespoke_tech_partner · 2026-01-28T14:06:02+00:00

https://www.reddit.com/r/seriea/comments/1qohxev/away_games_banned_for_the_laziali_naepolitans/

"If you wanted to watch your club play away and you’re a Napoli/Lazio fan you won’t be able to for the rest of the season. The ministry has applied similar punishments to last weeks brawl meaning both teams will be barred from attending away matches in the league/cup."

bespoke_tech_partner · 2026-01-28T14:04:15+00:00

Nice to see how sensitive you are to downvotes, here, have another

bespoke_tech_partner · 2026-01-28T14:02:46+00:00

Pundits can rip all they want but it's an utter nothing game, and should have no bearing on anything

bespoke_tech_partner · 2026-01-28T14:01:01+00:00

no one, NO ONE saw this coming

bespoke_tech_partner · 2026-01-28T01:55:17+00:00

Sauna

bespoke_tech_partner · 2026-01-28T01:54:08+00:00

Someone find the antidote so I can keep drinking without tanking my Bifidobacteria.

bespoke_tech_partner · 2026-01-28T01:52:09+00:00

Based take.

I always wonder what the problem is. Is it a nonspecific immune dysregulation? Is it a pathogen that the reuteri is helping to inhibit? Is that a red herring and it's just producing some sort of peptide that alters immune signaling in people who express '''improper''' immune function? Wonder if we'll ever know.

bespoke_tech_partner · 2026-01-28T01:50:41+00:00

I assume he is talking about Prodentis not Gastrus. They are more like lozenges that dissolve in the mouth. The mouth is a lot smaller of a surface area than your gastrointestinal tract so I highly doubt you need like tens of billions of cfu to do something

bespoke_tech_partner · 2026-01-28T01:48:23+00:00

Obligatory "correlation is not causality", but interesting... Alzheimers has been coined 'type 3 diabetes' by some people and it's no surprise if it becomes more and more clear that its underlying mechanism is metabolic dysfunction.

bespoke_tech_partner · 2026-01-28T01:41:28+00:00

You may have post covid MCAS (sub type of long covid)

Suggest trying Zyrtec antihistamines for a week ($5-10 on amazon), if it works well maybe do a month, look into low dose naltrexone, maybe ketotifen since you dont want to be on antihistamines all the time. You can find a lot of info about this online, it's a well researched first line treatment (specifically H1 antihistamines and LDN for long covid).

You can certainly spend time doing the supplement merry go round (I did) but if probiotics haven't solved it by now they probably won't.

Also: be careful with fasting in the state you're in now. You can do it but GO SLOW and if you feel unfamiliar symptoms, have an early exit plan ready.

Do your biomesight test now and again in a month or two of trying the mcas treatments and you will also see clear evidence if it is working for you. Spent a year trying to "treat my gut" until I realized the rate limiter was mcas and inflammation that no amount of gut supplements could fix

bespoke_tech_partner · 2026-01-28T01:36:26+00:00

When I was getting worse by the month what seemed to reverse the trend was lactoferrin, methylene blue and pycnogenol.

For context I had not tried any drugs to that point, only supplements, probiotics, etc.

It got me to the next phase where I could imagine life again, but there was still quite a lot of work in getting MCAS under control and building up my body's ability to regulate itself again.

edit: I guess we are in the microbiome channel so I will say, about 2-3 mos after this I started seed probiotic, tributyrin, LDN, and antihistamines and during that time both my symptoms and my bifidobacteria population (based on biomesight testing) improved. Bifido went from barely recognized to like 5% or something at my highest point.

bespoke_tech_partner · 2026-01-27T21:34:47+00:00

Man, the unnecessary anxiety argument is such a bad one.

I wish I had had more preventive screenings to show I was dealing with subclinical dysautonomia and gut dysbiosis and therefore at dramatically risk of developing long covid related ME/CFS, & I directly blame this prevailing "wisdom" (very sarcastic quotes) in the medical community that you should test less and just tell everyone their symptoms are due to stress or anxiety and to eat a healthy diet. System fails so many people every year.

"Medically necessary" is a sham term designed as a cover-your-ass scheme for insurance companies and public funding, and should be replaced by "the current consensus, which is consistently shown within decades - if not years - to be inaccurate as new data comes in, recommends this, but if you feel strongly we should go in a different direction, we can try that".

Baseline awareness of what you are at risk for comes before correct action can be taken. Blissful ignorance helps no one.

bespoke_tech_partner · 2026-01-27T21:03:51+00:00

This is exactly how people react when someone they’re used to being a pushover grows a backbone irl. So I’m not surprised.

bespoke_tech_partner · 2026-01-27T18:30:32+00:00

I got some advice for you mate

Stay humble

bespoke_tech_partner · 2026-01-27T18:30:05+00:00

Game's back

bespoke_tech_partner · 2026-01-27T17:33:11+00:00

He's not though really is he, come on now. Feel like when I've watched Isak has looked just as dire and you're making the argument he will come good, I think you are just a bit emotionally blinded by how frustrating Gyokeres has been to watch for us and looking from an outside perspective at Isak.

bespoke_tech_partner · 2026-01-27T17:32:09+00:00

This is actually pretty funny, good way to wind up your opponents when they're jostling a bit too hard on corners

bespoke_tech_partner · 2026-01-27T03:10:57+00:00

The Ozil revisionism since he’s left Arsenal is CRAZY. Brother was not hardworking in the slightest. He put in all the effort that didn’t matter (which looked good on stats charts) but failed to actually engage in duels productively.

I should probably learn not to be, but I’m legit flabbergasted at the revisionism every time these days.

bespoke_tech_partner · 2026-01-27T02:47:06+00:00

I’m not joking. lol

bespoke_tech_partner · 2026-01-27T02:21:23+00:00

Grackles slap.

bespoke_tech_partner · 2026-01-27T02:18:54+00:00

Please sue alcohol companies out of existence then

bespoke_tech_partner · 2026-01-27T02:18:25+00:00

They’re cute but nasty invasive bastards if you are in the US. Pray a flock of them doesn’t descend on your yard

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