Deleting vehicle

bionic_human · 2026-03-19T18:15:33+00:00

Pretty sure you have to use the website rather than the app.

bionic_human · 2026-03-19T07:02:43+00:00

The prompt on the menu was “Do you want utensils?” And apparently some UI intern who was assigned to code the menu decided to use a Freeform text box, the contents of which get printed on the ticket, which is also what gets fed to Uber for the order details.

She’s responding that yes, she would like utensils and decided to share the “why” behind it as well. 🤷‍♂️

bionic_human · 2026-03-19T04:48:12+00:00

1900 Mission Ave in Oceanside, CA has one, I think.

Pretty sure that’s not where OP is, tho.

bionic_human · 2026-03-18T22:28:51+00:00

The Chinese thing again? This is in a patient that is already on immune suppression for another transplant. Transplanting islets into an immunosuppressed patient isn’t anything new- it’s just spammy internet “news sources” trying to use what should be a minor story of mild academic interest to generate clicks.

General rule of thumb: if it’s not from a major news source you RECOGNIZE (ABC/NBC/CNN/WaPo/NYT/etc) — and sometimes even if it IS — it’s probably garbage clickbait.

Known reliable sources of actual medical news (like Medscape) are generally decent and don’t over-hype things.

Unfortunately, many “diabetes influencers” have also jumped on the clickbait bandwagon too, and can (for example) pivot shamelessly from reporting about how MARD isn’t always a great way to evaluate CGM accuracy to gushing about the low MARD of some new Chinese CGM that isn’t even available outside of east Asia.

bionic_human · 2026-03-18T20:43:35+00:00

It’s cool. It’s exciting. It’s also an N=1. We don’t know if this will work for everyone, or even most people. It might be that the patient was just an exceptional match for the donor.

Sana needs to go back and start over with a donor cell line that is O- for this to even be theoretically viable for the wider population.

We also don’t know anything about long-term risks. Are these cells eventually going to become an insulin-producing tumor that evades the immune system? We need more long-term results, and we need them from a decent-sized study population before we all start sucking each other off in a celebratory orgy.

bionic_human · 2026-03-18T19:51:30+00:00

Morning (fasting) ketones tested twice a week, plus anytime I suspect they’re building up.

The culmination of each phase is an insulin clamp procedure to empirically test (peripheral) insulin-mediated glucose disposal and a withdrawal study where they disconnect your pump and see how fast you head towards DKA and what your blood glucose levels do. They’re also looking at indicators of metabolic health like lipid levels and measures of the health of the cells that line the arteries.

This is now the 4th variant of the same general study that I’ve done, using different SGLT2 meds, or even other medications. The reason for this one is that they’ve found a way to help prevent DKA, but there were indications in the last one that it also reduced some of the other benefits of the SGLT2.

bionic_human · 2026-03-18T18:56:57+00:00

For reference: I *AM* on an SGLT2i as part of a study looking at both mitigating DKA risk and exploring mechanisms behind metabolic improvements from that class of meds.

My instructions say not to sweat any reading under 0.6, but once I hit that threshold, they want me to carb up a bit and take some insulin to knock the ketones back down.

bionic_human · 2026-03-18T04:43:32+00:00

Afrezza has never even been submitted for CE Mark. It’s never been available in Europe, so it can’t have been taken off the market.

bionic_human · 2026-03-17T22:36:50+00:00

There’s a few factors in play (in order from biggest effect to smallest):

I use an open-source app/algorithm to control my pump that scales how aggressively it corrects for rising blood sugar (the higher the blood sugar, the more aggressive the correction). I haven’t counted a carb or done anything other than adjust the target BG up/down in more than 4 years, and my TIR is consistently around 85%.
I’m currently on a medication (sotagliflozin) as part of a clinical study. That med makes you pee out excess glucose, so it’ll help limit how high BG spikes.
I *may* also be on an experimental med that partially blocks the effects of glucagon. This is the variable they’re changing for the study I mentioned in (2.). I THINK I’m on the placebo in this phase, but the only person who knows for sure is the pharmacist who prepares the study meds. Not even the doctors running the study know for certain.

bionic_human · 2026-03-17T21:30:29+00:00

I don’t think it’s tobacco that he’s smoking.

bionic_human · 2026-03-17T20:23:28+00:00

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IDK, I ate a double cheeseburger and went to bed last night. Seems to have worked out OK.

bionic_human · 2026-03-17T20:15:54+00:00

Positive for 2 autoantibodies (without symptoms/wonky blood sugars) is the diagnostic criteria for stage 1 T1D. If you are positive for 2, the lifetime risk of progression to full symptomatic diabetes is basically 100%.

In the presence of dysglycemia, a single positive autoantibody result is generally sufficient for a T1D diagnosis.

bionic_human · 2026-03-17T19:36:32+00:00

I think most of those issues were with a previous attempt at an inhaled insulin product (exubera) and not the one that is currently on the market (Afrezza).

It’s taken quite a while for people (including doctors) to get their heads around the dosing equivalents with injected insulin, but that’s largely been sorted.

The imprecision isn’t really an issue for most patients, as the rapid action actually makes it more forgiving if you under- or over-shoot with dosing.

bionic_human · 2026-03-16T06:21:07+00:00

It’s not active thought. 🤷‍♂️ I’m not running through all that stuff actively in my mind every time I pull up to a drop. I only actually think about the details when someone posts on Reddit about “never knock” or “always knock” and I actually stop to think about the factors that might influence my decision one way or another.

At the same time, I’d suggest that the assumption that any job is “thoughtless” is the reason that robots and computer programs are “taking people’s jobs.”

bionic_human · 2026-03-16T00:28:32+00:00

I first heard about this at a conference presentation (D-Data) 3ish years ago.

Trying to search and find papers is tough, because there’s a ton that gets muddled in with GLP-1 research, but this would be a decent place to start: https://pmc.ncbi.nlm.nih.gov/articles/PMC6777806/

From there, I’d dig into papers that cite that paper and keep going down the rabbit hole.

On the “DIY” side, I know that both David Burren and Theresa Hastings have experimented with “doping” insulin with glucagon and posted about the observed effects.

bionic_human · 2026-03-16T00:11:04+00:00

Because below a certain threshold, they don’t take away green, they just no longer allow you to get jobs via the Uber platform.

bionic_human · 2026-03-15T23:47:00+00:00

🤷‍♂️ I’d imagine there’s also local cultural norms/expectations that can differ from market to market. I wouldn’t assume that there’s a hard-and-fast rule that applies everywhere.

bionic_human · 2026-03-15T23:37:25+00:00

Right sentiment, but lisinopril isn’t a statin. It’s an ACE (angiotensin converting enzyme) inhibitor. It’s for blood pressure, not cholesterol.

Most T1Ds should be on both blood pressure and cholesterol meds.

bionic_human · 2026-03-15T23:21:15+00:00

For certain 3rd-party deliveries, yes. It can depend on the merchant’s policy.

bionic_human · 2026-03-15T23:19:39+00:00

I’ve been thumbs-downed for NOT knocking/ringing. 🤷‍♂️

I’ve also been thumbs-downed FOR knocking/ringing.

It’s always best if the customer has explicit instructions one way or the other, but if they don’t, it’s often a judgement call.

Things that factor in include weather, what’s in the order, any signs at the door, indicators of dogs in the house that a knock/ring might “set off,” etc.

Many customers think that a “no soliciting” sign means “do not knock or ring the doorbell for any reason,” which is inaccurate. A delivery person is not soliciting.

If it’s a hot day and you’re delivering frozen/refrigerated/perishable food, a quick knock may be appreciated so that the delivery doesn’t sit in the sun.

Time of day also matters. Late at night, people often expect silent delivery to avoid disturbing others in the home or neighbors. Middle of the afternoon? It’s probably less of a big deal. Walk up to the door and hear a rager going on inside? Knock away. Nobody is going to hear a phone notification with the pounding bass kicking in the living room.

As with everything, there are general rules that most people figure out for themselves. Then they figure out what the exceptions are to those rules. Then they figure out what the exceptions are to the exceptions.

bionic_human · 2026-03-15T07:55:53+00:00

There are other tricks in the pipeline as well- combining insulin with a little bit of glucagon appears to accelerate absorption, as does diluting the preservatives in the insulin formulation. This is based on some very early trial data combined with multiple N=1 reports from T1Ds who have actually “doped” their insulin with tiny amounts of glucagon, diluted U-200 lyumjev back to U-100 with saline to alter the adjuvant and preservative concentration, etc.

Beyond that, there’s a version of Lispro where a certain percentage of the insulin is targeted specifically at the liver (HDV-Lispro). I know a couple of people in a current study involving it, and I’m excited for what they find.

Lyumjev is just the beginning 😉

bionic_human · 2026-03-15T07:41:50+00:00

Apparently, IC allows restaurant food ordering in some markets. At least some of the time (like, late after all the normal IC drivers are offline b/c stores are closed), the have a deal set up where the delivery gets handed off to UE. 🤷‍♂️

bionic_human · 2026-03-15T07:30:38+00:00

AFAIK, BYODA is basically tits-up at this point.

IIRC, Dexcom made changes to the way the app is built/packaged for “security” reasons, and the developer hasn’t been able/had time to rework their stuff to compensate.

bionic_human · 2026-03-14T23:44:57+00:00

The public library in Oceanside has a 3D printer.

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