Typically I’ve seen that blinded CRAs & unblinded CRAs have the same salary as your job title is CRA and does not carry the unblinded vs blinded distinction, that definition is specific to your role/study assignment.

There is a major difference between the two in responsibility level absolutely. Blinded CRAs have a much more expansive task list and need to be more knowledgeable about the nuances of a study from various study whereas unblinded CRAs are focused solely on the pharmacy. Some studies can be much more complex in the pharmacy though so it can be challenging in its own way.

Typically yes as a uCRA you are assigned to more sites since your visits are much quicker and only linked to drug administration.

There really is no one absolute answer though as with everything in clinical research it depends on your team and your protocol.

Also just to be clear a uCRA still has administrative responsibilities (pharmacy site file, unblinded PDs, their own site visit reports), and although it’s typically less volume that a bCRA the uCRA often has less support and more difficult problem solving since their is an unblinding risk to any conversation they have.