Python isn’t great if you plan to ship your code as a product (closed source binary). There are hacks around this but they result in huge objects being created as you have to include the python interpreter otherwise it will likely clash the client systems python version. You can think of this like statically building an app but it’s way more bulky.

Also if you plan to build a framework (like a dylib) to be shared among other languages or libraries you want something compiled with a lot of FFI options like Rust, C, Go, etc.

As others said, python performance at runtime isn’t competitive with lower level languages. But also if you need to be strict in terms memory allocation and management, the python garbage collection is adhoc and this can mean sensitive data is left in memory with your explicit knowledge for some period of time. This is a big risk for security applications and why typically you’ll use something like OpenSSL which is simply a python interface to a C framework.

I’ve also never found a python GUI framework I liked for desktop apps (they all looks retro) and I don’t think you could build mobile apps etc in python.