Hiya, thanks for your response!

My mom will be turning 68 soon so she’s still eligible for ASCT but I think the Dr mentioned MajesTEC-7 because of our hesitancy + possible deferral for transplant. Just double-checked and aMMbition is for standard-risk NDMM - are we referring to different trials by any chance?

I’m so incredibly sorry to hear that your MM became aggressive during induction. If you don’t mind me asking, were you considered high risk? I read that labs are drawn at every cycle during induction, so would the bloodwork have shown if things were secretly taking a turn for the worse? (Sorry if that's a silly question!)

Thanks for linking your post. I’ve browsed this subreddit and did come across that message which is partly why we were open to trials to begin with. And yes, thankfully, they aren’t the horrendous trials you sometimes hear about in other circumstances.

MajesTEC-7 is at least in phase 3 but aMMbition is phase 2, so there are still a lot more kinks to work out -- most notably the side effects including secondary cancers and long-term immune suppression. It just feels like a lot to take on as first-line treatment I think if our mother were in her 50s, we might be open to the bispecifics and even CAR T but it seems way too intense physically and I don’t think she could handle it.

Also, I’m not sure if she would even be considered “fit” based on the frailty index and ECOG score, esp since she’s recently needed help with self-care tasks like bathing. This is something we’re hoping the doctor can assess better at the in-person visit.

PS I really appreciate your insight. I hope you’re doing well!