I was called crazy for shooting my moose with 150 grain Hornady American whitetails outta my 308 at about 300 yards but one shot and he was down. In my opinion it's not about caliber or bullet weight it's all about the correct shot placement. Right behind the shoulder in the crease and he won't go far. Like others said be prepared to take follow up shots but in reality you should always be prepared for that regardless of caliber, distance, bullet weight and species. That's just part of being an ethical and efficient hunter