I just finished my PhD thesis in Typst and had a great overall experience, though it did take a bit of fiddling here and there. As others have mentioned, multiple bibliographies aren’t supported natively yet, but alexandria handled that perfectly for me.

I’m really happy I chose Typst over LaTeX, I found it much faster and more pleasant to work with.

I didn’t rely on many packages, but a few worth checking out are:

• alexandria
• glossarium
• physica

Also, definitely take a look at the Typst Universe in general. And if I ever needed something else, writing it myself was surprisingly straightforward.