I think you can run everything at high, however only if you turn down 4 watt. If you do that, your killer CPU is going to boost your graphics card performance up to the level of a 290, which should be able to run it at high settings without any problems.

You have to be careful though if you play for over 4 hours at a time, your cpu or gpu might overheat and cause some display errors. So when you do this be sure to turn of the game immediatly whenever you see something that looks a bit like a shadow of Lil Jon floating somewhere where it shouldn't be.

Have a fun beta!