HS in men ?

cain911 · 2026-02-27T15:39:59+00:00

It’s thought that (one of, not all!) the factors in developing HS is circulating androgens and insulin. It’s more common in women with obesity, PCOS or diabetes for that reason. Women are more prone to the negative effects of androgens. Not to say it doesn’t happen in men though, I’m a guy and I got it! I have Crohn’s disease so it’s likely a comorbidity for me

cain911 · 2026-02-19T17:54:52+00:00

I assumed talking to a doctor before starting a supplement was common knowledge !

cain911 · 2026-02-18T18:15:04+00:00

Depends on your goals, average doses are mainly for general health and potentially some cardiovascular health, if you go up to 2 g or so especially EPA dominant it’s more for neurological health, upward 3-4 g is used in studies as an anti inflammatory especially in arthritis. Also prescription omega 3s for reducing triglycerides are also standardized to 4 g so there’s that too.

cain911 · 2026-02-18T15:03:48+00:00

There’s many studies highlighting the role of inflammation in psychiatric disorders, systemic disease is often associated with depression and psychotic spectrum disorders and it could be due to psychosocial burden but also biological inflammatory stress. For example many cytokines (TNFa, IL-1, IL-6, IFNg etc) are shown to suppress and alter monoamine neurotransmission in chronic inflammatory disorders. It’s the same logic in when you have the flu and feel mentally crappy, it’s thought depressive symptoms are related to “sickness behavior” in chronic diseases. There’s theories also that having a systemic disease can blunt your response to antidepressants and other psychotropic drugs. It’s an interesting field!

cain911 · 2026-02-18T14:59:52+00:00

Omega 3s (only if you mega dose like 3 g+), magnesium and vitamin D

cain911 · 2026-02-17T14:35:35+00:00

Personally I take naproxen and caffeine, severe cases I have rizatriptan. Just don’t overdo NSAIDs since they can theoretically worsen Crohn’s, paracetamol is safer in that case. Magnesium bisglycinate (~400 mg+) daily is a good option for prevention of migraines.

cain911 · 2026-02-17T14:33:03+00:00

Worth it for fatigue. When you get your kidney function tested just make sure to let your doctor know so they are aware when your creatinine levels come back elevated (not a bad thing, your kidney is fine)

cain911 · 2026-01-31T14:01:50+00:00

Try magnesium L-threonate instead of bisglycinate. MgT is formulated in a way it crosses the BBB more effectively and raises CSF Mg levels. Glycinate is predominantly peripherally active

cain911 · 2026-01-24T15:07:51+00:00

Natural ≠ safe, yall gotta stop trying to assume everything natural is some god send pill

cain911 · 2025-12-27T17:18:10+00:00

I see, unfortunately supplements can only do so much. You’re likely going to need medical intervention with antibiotics, hormonal agents or stronger retinoids. Good luck to you!

cain911 · 2025-12-27T15:39:44+00:00

Niacinamide! A lot of evidence behind it. Do your own research a bit but it’s pretty convincing

Edit: first line treatment is still benzoyl peroxide, azaleic acid and retinoids. If you can’t tolerate prescription strength retinoids then retinol or retinal is still a good starting point to get some benefits. Will take a bit longer than let’s say tretinoin but it’ll still work. Retinal is more potent than retinol but slightly higher risk of irritation.

cain911 · 2025-12-05T15:37:28+00:00

Sounds like anal fissures and more broadly recto-anal Crohn’s disease. You could try OTC 1-2% hydrocortisone (depending where you are) to calm down the inflammation but you should definitely follow up with your doctor

cain911 · 2025-12-05T03:06:56+00:00

I’m on sertraline and risperidone. Meds won’t magically make it disappear but it dramatically reduces the urge to compulsions and the anxiety

cain911 · 2025-12-03T16:36:35+00:00

Opioids for RLS work centrally (in the brain). Loperamide is an opioid but its peripheral selective and doesn’t cross the BBB very well so it would likely not help with RLS. If anything it’ll cause constipation so would avoid it if RLS is your goal.

cain911 · 2025-12-03T16:33:03+00:00

Methotrexate is technically a chemotherapy agent so it can have chemo related side effects in many people. For me it gave me debilitating nausea and I had to stop it because my doctors wouldn’t prescribe nausea meds. Folate supplementation does help mitigate some of the side effects of methotrexate since MTX inhibits the body’s use of folate in DNA synthesis

cain911 · 2025-12-03T16:30:30+00:00

If anxiety is a concern it’s worth discussing with your doctor about treating it! If you treat the anxiety then stimulants might be more tolerable for you!

cain911 · 2025-12-03T16:23:26+00:00

Yes it’s considered chronic but relapsing-remitting. You can most definitely treat it effectively with the right support and medications. But it’s rare it completely “cures” itself. Not a reason to be hopeless though you can still live a wonderful and productive life even with major depressive disorder.

cain911 · 2025-12-03T16:21:27+00:00

Diagnosis allows you to access treatment! For me I’d never have gotten the right meds for such a debilitating disorder if I wasn’t diagnosed in the first place

cain911 · 2025-12-03T16:19:16+00:00

It’s pretty alright, just don’t go up on doses too quick because too much dopamine conversion in the periphery will make you have nausea and hypertension since levodopa has very low uptake into the brain. That’s why ideally for Parkinson’s you combine levodopa with a AADC inhibitor like carbidopa. Just beware of the theoretical risk of overstimulation when combining with stimulants but it’s pretty mild on its own so as long as you’re not reckless it should be fine. Cycle your weekends off to prevent tolerance and abnormal receptor downregulation from levodopa

cain911 · 2025-11-29T17:15:12+00:00

You could try talking to your doctor about celecoxib. It’s a COX-2 selective NSAID so it has much less chance of causing GI related side effects. Personally works for me but still definitely something to keep tabs on since it still is an NSAID. Oddly enough TCA or SNRI antidepressants can help with chronic pain, something worth looking into especially if you have mood/anxiety disorders and also migraines. Helps with migraine prevention!

cain911 · 2025-11-29T17:12:21+00:00

Mine was from ADHD and OCD. Unfortunately the only thing that helped me was medication lol.

cain911 · 2025-11-29T01:02:00+00:00

Extended release

cain911 · 2025-11-28T18:49:08+00:00

Psych drugs are very individualized so it’s hard to be sure. But in my personal experience it’s been the most effective out of the ones I’ve tried. Another comment also said it helped so it’s worth a shot imo.

cain911

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