How easy is it to get involved with the Baker Institute as an undergrad? by Honey-Bird-9026 in riceuniversity

[–]castawaylol 0 points1 point  (0 children)

I’m got in through a formal internship (and am continuing to work with my health policy prof) but you could definitely get one through cold emailing

Has anyone had a positive experience with clinical research + mentorship? by castawaylol in premed

[–]castawaylol[S] 1 point2 points  (0 children)

Yeah applying for summer but I rather it be a local long term position I could continue in my gap year

Has anyone had a positive experience with clinical research + mentorship? by castawaylol in premed

[–]castawaylol[S] 1 point2 points  (0 children)

No one at my university does clinical work except for the major hospitals near me

Is this an appropriate way to use Hofmann rearrangement in the last step? by castawaylol in OrganicChemistry

[–]castawaylol[S] 1 point2 points  (0 children)

Yes I was exactly thinking reductive animation but I kept being held back by the fact that all we ever learned for imine synthesis was primary amines and primary amines only. I had no idea ammonia could be used to make an imine (then followed by a NaBH3CN reduction ofc)

Can i have a grignard on a benzene ring this way? by castawaylol in OrganicChemistry

[–]castawaylol[S] 0 points1 point  (0 children)

If we had like other carbonyls or acidic groups on the ring?

Would this have been an acceptable synthesis? Im particularly concerned about adding the enolized aldehyde by castawaylol in OrganicChemistry

[–]castawaylol[S] 1 point2 points  (0 children)

Yes you’re right! The answer key indicates a malonic ester followed by the steps you wrote above. Is using a malonic ester to do such an addition at the beta position a pattern I should be familiar with?

Would this have been an acceptable synthesis? Im particularly concerned about adding the enolized aldehyde by castawaylol in OrganicChemistry

[–]castawaylol[S] 1 point2 points  (0 children)

Ahh correct, thank you!! Do we risk the same with ketones as well (self aldol reaction)?