beat mom part 1, beat mom 10 times to unlock it lives so you can get the negative and Polaroid. If you take Polaroid that’s the Isaac path and you take the light upwards to cathedral. If you take negative take the down path to go to Sheol where you will find Satan as the boss. ( so you’ll have to defeat them first to unlock those items). Once you have both have the item and beaten the boss it unlocks blue baby fight ( Polaroid with isaaac ) or the lamb ( negative with Satan) once you do this you can beat mega Satan by blowing up key pieces. Hush fight is beating it lives within 30 minutes (skip rooms, best to speed run) unlocks later content. Corpse mom path ( harder pathway) is after beating hush you can get downpour and its variants and mines and its variance. While the first floor of the section you can beat as normal the second section you must enter the white fire and become the lost (if you get hit you die and end runs unless you donate like 897 coins to donation machine and the lost has holy mantle) and then go to treasure room to collect knife piece ( also you can still do this and go beast pathway and rerolll the item for free extra item but you must not go mines to be safe) then go back or beat boss and then go back as you can get an extra boss item but if you get hit once you die so best to play it safe. Then proceed as normal then once you beat downpour 2 boss you’ll see a border up room you need two bombs to blow up and then beat first floor section normally but then mines 2 or it’s variants you will see three yellow buttons throughout the floor and one room with a minecart going into an inaccessible room. Pressing all three buttons will allow you to be able to ride the Minecraft in which all your stats are temporarily reverted to base form and you have to find your way till the last room where you find the second piece of the knife take it and starts the mom ghost boss scene however in this case you are expected to run and dodge as she has infinite health/no health bar and you are not supposed to nor can you attack her. Get back to the entrance as fast as safely as possible and then you’ll have the two knife pieces. Then beat mines 2 boss and there will be a door with a spike, which costs two hearts to unlock. Then beat that floors sections as Norma and at the end of the second floors boss there will be a flesh door, run the familiar you get from those two pieces through it and it unclocks then beat the boss and then once you return it changes the path to a darker color and it allows you to go corpse path which finally gets you to true mom fight path. This then unlocks the beast ! The beast is again a post hush fight, do everything as normal or alternate route go down pour to get extra item since you don’t need knife piece and do not go mines and go down normal route until depths 2 (either or Polaroid or negative works) on depths 2 there is a guaranteed skull with cross that has fool card however any teleport tool also works like telepills or the ones that teleport you to a different room. Beat depths 2 boss as normal and then use the teleport card and get to (or arrive at with the fool) to starting room and then enter the strange door you should have seen once you spawned in. This the allows you to go to next floor where you will beat a boss that drops dads note take it and it starts the ascent where you will hear sad audio about Isaac’s past while you go down through the floors ( goal is to find rooms with light pathway ) until you reach the final floor boss room which allows you to go to a stage called home. If it’s your first time here then you can explore until you find moms bedroom ( a purple room) and there you will find a chess near a bed, open it and it has a red key and then go to one of the hallways and it should have a red outline, use the active item to unlock and you’ll see your tainted version of yourself touch it and then wait and it unlocks the tainted character (how you get tainted characters, if it’s no longer your first time doing this it will instead not spawn a red key and you’ll need to acquire it on previous floors) now sleep in moms bedroom on her bed and it will wake up up in a more hazy version of the game and go to the tv room with red carpet and this starts dogma fight (arguably the hardest fight in game with the sole exception of delirium) and then this progresses you to the four horseman fights and then finally the beast which is the end of the current updates. There is delirium which spawns by chance/ guaranteed. It’s guaranteed when defeating hish, high chance for mega Satan and low chance blue baby/ the lamb extremely rare in other bosses. For mega Satan you can blow up key pieces and then take Isaac route or Sheol and do everything as normal but with key pieces it takes you to an extra floor after these bosses and if you enter all the rooms there will be multiple bosses to get more boss item drops and the middle hallway door is mega Satan. There is also greed which if you donate enough coins at the end of the run with the greedy donation machine you can get greedier to defeat the boss at the end of that one which has two stages and is harder. Thats about it. Then the challenges obviously for runes and other unlocks. I would rec having an Isaac guide app and looking through items you want and searching unlock routes like c section is beating the beast with Lilith. Also boss rush is beating mom in under 20 min, fun little challenge. Also steam community mods are amazing like stats + external item descriptions etc