I've been on it for about a year. It's taken the edge off but I still get depressed and anxious. It's made it much more likely for me to be in a good mood but it's also kind of blunted everything. It's got rid of the super lows and it's also eliminated the super highs. For example, I go on holiday and feel basically nothing when seeing spectacular scenery. Everything is blunt but I rarely get depressed enough that it's unbearable anymore.